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An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae

Irradiance is an important factor influencing the acceleration of microorganism mortality in photodynamic inactivation (PDI) processes. Experimental observations of PDI processes indicate that the greater the irradiation power is, the faster the decrease in the population size of microorganisms. How...

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Autores principales: Brasel, Michal, Pieranski, Michal, Grinholc, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447635/
https://www.ncbi.nlm.nih.gov/pubmed/32843677
http://dx.doi.org/10.1038/s41598-020-71033-7
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author Brasel, Michal
Pieranski, Michal
Grinholc, Mariusz
author_facet Brasel, Michal
Pieranski, Michal
Grinholc, Mariusz
author_sort Brasel, Michal
collection PubMed
description Irradiance is an important factor influencing the acceleration of microorganism mortality in photodynamic inactivation (PDI) processes. Experimental observations of PDI processes indicate that the greater the irradiation power is, the faster the decrease in the population size of microorganisms. However, commonly used mathematical models of PDI processes usually refer only to specific values of irradiance without taking into account the influence of change in irradiance on the dynamic properties of inactivation. The main goal of this paper is to analyze the effect of irradiance on the PDI process and attempt to mathematically model the obtained dependencies. The analysis was carried out using the example of photodynamic inactivation of the bacterium Streptococcus agalactiae with the adopted Logistic PDI model optimized for several selected levels of irradiance. To take into account the impact of changes in irradiation power on the PDI model, the selected parameters were made appropriately dependent on this factor. The paper presents several variants of parameter modification with an evaluation of the model fitting quality criterion. The discussion on appropriate selection of parameters to be modified was carried out as a comparative analysis of several case studies. The extended logistic PDI model obtained in the conducted research effectively describes the dynamics of microorganism mortality in the whole tested irradiation power range.
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spelling pubmed-74476352020-08-26 An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae Brasel, Michal Pieranski, Michal Grinholc, Mariusz Sci Rep Article Irradiance is an important factor influencing the acceleration of microorganism mortality in photodynamic inactivation (PDI) processes. Experimental observations of PDI processes indicate that the greater the irradiation power is, the faster the decrease in the population size of microorganisms. However, commonly used mathematical models of PDI processes usually refer only to specific values of irradiance without taking into account the influence of change in irradiance on the dynamic properties of inactivation. The main goal of this paper is to analyze the effect of irradiance on the PDI process and attempt to mathematically model the obtained dependencies. The analysis was carried out using the example of photodynamic inactivation of the bacterium Streptococcus agalactiae with the adopted Logistic PDI model optimized for several selected levels of irradiance. To take into account the impact of changes in irradiation power on the PDI model, the selected parameters were made appropriately dependent on this factor. The paper presents several variants of parameter modification with an evaluation of the model fitting quality criterion. The discussion on appropriate selection of parameters to be modified was carried out as a comparative analysis of several case studies. The extended logistic PDI model obtained in the conducted research effectively describes the dynamics of microorganism mortality in the whole tested irradiation power range. Nature Publishing Group UK 2020-08-25 /pmc/articles/PMC7447635/ /pubmed/32843677 http://dx.doi.org/10.1038/s41598-020-71033-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Brasel, Michal
Pieranski, Michal
Grinholc, Mariusz
An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae
title An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae
title_full An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae
title_fullStr An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae
title_full_unstemmed An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae
title_short An extended logistic model of photodynamic inactivation for various levels of irradiance using the example of Streptococcus agalactiae
title_sort extended logistic model of photodynamic inactivation for various levels of irradiance using the example of streptococcus agalactiae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447635/
https://www.ncbi.nlm.nih.gov/pubmed/32843677
http://dx.doi.org/10.1038/s41598-020-71033-7
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