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Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention

PURPOSE OF REVIEW: Omics-based technologies were suggested to provide an advanced understanding of obesity etiology and its metabolic consequences. This review highlights the recent developments in “omics”-based research aimed to identify obesity-related biomarkers. RECENT FINDINGS: Recent advances...

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Autores principales: Aleksandrova, Krasimira, Egea Rodrigues, Caue, Floegel, Anna, Ahrens, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447658/
https://www.ncbi.nlm.nih.gov/pubmed/32594318
http://dx.doi.org/10.1007/s13679-020-00393-y
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author Aleksandrova, Krasimira
Egea Rodrigues, Caue
Floegel, Anna
Ahrens, Wolfgang
author_facet Aleksandrova, Krasimira
Egea Rodrigues, Caue
Floegel, Anna
Ahrens, Wolfgang
author_sort Aleksandrova, Krasimira
collection PubMed
description PURPOSE OF REVIEW: Omics-based technologies were suggested to provide an advanced understanding of obesity etiology and its metabolic consequences. This review highlights the recent developments in “omics”-based research aimed to identify obesity-related biomarkers. RECENT FINDINGS: Recent advances in obesity and metabolism research increasingly rely on new technologies to identify mechanisms in the development of obesity using various “omics” platforms. Genetic and epigenetic biomarkers that translate into changes in transcriptome, proteome, and metabolome could serve as targets for obesity prevention. Despite a number of promising candidate biomarkers, there is an increased demand for larger prospective cohort studies to validate findings and determine biomarker reproducibility before they can find applications in primary care and public health. SUMMARY: “Omics” biomarkers have advanced our knowledge on the etiology of obesity and its links with chronic diseases. They bring substantial promise in identifying effective public health strategies that pave the way towards patient stratification and precision prevention.
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spelling pubmed-74476582020-09-02 Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention Aleksandrova, Krasimira Egea Rodrigues, Caue Floegel, Anna Ahrens, Wolfgang Curr Obes Rep Metabolism (M Dalamaga, Section Editor) PURPOSE OF REVIEW: Omics-based technologies were suggested to provide an advanced understanding of obesity etiology and its metabolic consequences. This review highlights the recent developments in “omics”-based research aimed to identify obesity-related biomarkers. RECENT FINDINGS: Recent advances in obesity and metabolism research increasingly rely on new technologies to identify mechanisms in the development of obesity using various “omics” platforms. Genetic and epigenetic biomarkers that translate into changes in transcriptome, proteome, and metabolome could serve as targets for obesity prevention. Despite a number of promising candidate biomarkers, there is an increased demand for larger prospective cohort studies to validate findings and determine biomarker reproducibility before they can find applications in primary care and public health. SUMMARY: “Omics” biomarkers have advanced our knowledge on the etiology of obesity and its links with chronic diseases. They bring substantial promise in identifying effective public health strategies that pave the way towards patient stratification and precision prevention. Springer US 2020-06-27 2020 /pmc/articles/PMC7447658/ /pubmed/32594318 http://dx.doi.org/10.1007/s13679-020-00393-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Metabolism (M Dalamaga, Section Editor)
Aleksandrova, Krasimira
Egea Rodrigues, Caue
Floegel, Anna
Ahrens, Wolfgang
Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
title Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
title_full Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
title_fullStr Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
title_full_unstemmed Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
title_short Omics Biomarkers in Obesity: Novel Etiological Insights and Targets for Precision Prevention
title_sort omics biomarkers in obesity: novel etiological insights and targets for precision prevention
topic Metabolism (M Dalamaga, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447658/
https://www.ncbi.nlm.nih.gov/pubmed/32594318
http://dx.doi.org/10.1007/s13679-020-00393-y
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