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IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas

The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for cell proliferation, survival, and anti-apoptosis. Thus, targeting IGF-1R appears as a reasonable rationale for tumor treatment. However, clinical studies showed that inhibition of IGF-1R has very limited effica...

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Detalles Bibliográficos
Autores principales:	Wang, Qing, Zhang, Yan, Zhu, Jiang, Zheng, Honggang, Chen, Shuntai, Chen, Li, Yang, Hsin-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447751/ https://www.ncbi.nlm.nih.gov/pubmed/32843616 http://dx.doi.org/10.1038/s41392-020-0204-0

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