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Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour

The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved m...

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Detalles Bibliográficos
Autores principales: Henriques, Sílvia F., Dhakan, Darshan B., Serra, Lúcia, Francisco, Ana Patrícia, Carvalho-Santos, Zita, Baltazar, Célia, Elias, Ana Paula, Anjos, Margarida, Zhang, Tong, Maddocks, Oliver D. K., Ribeiro, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447780/
https://www.ncbi.nlm.nih.gov/pubmed/32843654
http://dx.doi.org/10.1038/s41467-020-18049-9
Descripción
Sumario:The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in Drosophila melanogaster, Acetobacter pomorum (Ap) and Lactobacillus plantarum (Lp) a syntrophic relationship is established to overcome detrimental host diets and identify Ap as the bacterium altering the host’s feeding decisions. Specifically, we show that Ap uses the lactate produced by Lp to supply amino acids that are essential to Lp, allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for Ap to alter the fly’s protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets. These interactions also ensure the constant flow of metabolites used by the microbiome to alter reproduction and host behaviour.