Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment

Aberrant cell cycle machinery and loss of the CDKN2A tumor suppressor locus make CDK4/6 a potential target in pancreatic ductal adenocarcinoma (PDAC). However, a vast majority of PDAC cases do not harbor a durable response to monotherapy of CDK4/6 inhibitor. Utilizing remote loading to co-encapsulat...

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Detalles Bibliográficos
Autores principales: Ji, Ying, Liu, Xiangsheng, Li, Juan, Xie, Xiaodong, Huang, Max, Jiang, Jinhong, Liao, Yu-Pei, Donahue, Timothy, Meng, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447818/
https://www.ncbi.nlm.nih.gov/pubmed/32843618
http://dx.doi.org/10.1038/s41467-020-17996-7

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