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Clinical outcomes in men with prostate cancer who selected active surveillance using a clinical cell cycle risk score

AIM: To evaluate active surveillance (AS) selection, safety and durability among men with low-risk prostate cancer assessed using the clinical cell cycle risk (CCR) score, a combined clinical and molecular score. PATIENTS & METHODS: Initial treatment selection (AS vs treatment) and duration of A...

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Detalles Bibliográficos
Autores principales: Kaul, Sanjeev, Wojno, Kirk J, Stone, Steven, Evans, Brent, Bernhisel, Ryan, Meek, Stephanie, D’Anna, Richard E, Ferguson, Jeffrey, Glaser, Jeffrey, Morgan, Todd M, Lieb, Jeremy, Yan, Robert, Cohen, Todd, Ehdaie, Behfar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447833/
https://www.ncbi.nlm.nih.gov/pubmed/31483217
http://dx.doi.org/10.2217/pme-2019-0084
Descripción
Sumario:AIM: To evaluate active surveillance (AS) selection, safety and durability among men with low-risk prostate cancer assessed using the clinical cell cycle risk (CCR) score, a combined clinical and molecular score. PATIENTS & METHODS: Initial treatment selection (AS vs treatment) and duration of AS were evaluated for men with low-risk prostate cancer according to the CCR score and National Comprehensive Cancer Network guidelines. Adverse events included biochemical recurrence and metastasis. RESULTS: 82.4% (547/664) of men initially selected AS (median follow-up: 2.2 years), 0.4% (2/547) of whom experienced an adverse event. Two-thirds of patients remained on AS for more than 3 years; patient choice was the most common reason for leaving AS. CONCLUSION: The CCR score may aid in the identification of men who can safely defer prostate cancer treatment.