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Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 when used as a nutrition...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Kos Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Cocconcelli, Pier Sandro, Dierick, Noël, Glandorf, Boet, Herman, Lieve, Mantovani, Alberto, Prieto Maradona, Miguel, Saarela, Maria, Wallace, Robert John, Anguita, Montserrat, Pettenati, Elisa, Tarrés‐Call, Jordi, Ramos, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447873/
https://www.ncbi.nlm.nih.gov/pubmed/32874228
http://dx.doi.org/10.2903/j.efsa.2020.6019
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Dierick, Noël
Glandorf, Boet
Herman, Lieve
Mantovani, Alberto
Prieto Maradona, Miguel
Saarela, Maria
Wallace, Robert John
Anguita, Montserrat
Pettenati, Elisa
Tarrés‐Call, Jordi
Ramos, Fernando
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Dierick, Noël
Glandorf, Boet
Herman, Lieve
Mantovani, Alberto
Prieto Maradona, Miguel
Saarela, Maria
Wallace, Robert John
Anguita, Montserrat
Pettenati, Elisa
Tarrés‐Call, Jordi
Ramos, Fernando
collection PubMed
description Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 when used as a nutritional additive in feed and water for drinking for all animal species. The active substance is l‐lysine and it is produced in two different forms (monohydrochloride or sulfate salts). None of those forms pose any safety concern associated with the genetic modification of the production strain. l‐Lysine HCl and l‐lysine sulfate produced by C. glutamicum CGMCC 7.266 are considered safe for the target species, for the consumer and for the environment. For both products, the FEEDAP Panel has concerns regarding the safety for the target species when the additives are administered via feed and water for drinking, simultaneously. In the absence of data, the FEEDAP Panel cannot conclude on the safety of both forms of the additive for the user. The products under assessment are considered efficacious sources of the amino acid l‐lysine for all animal species. For these products to be as efficacious in ruminants as in non‐ruminant species, they require protection against degradation in the rumen.
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spelling pubmed-74478732020-08-31 Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Kos Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Cocconcelli, Pier Sandro Dierick, Noël Glandorf, Boet Herman, Lieve Mantovani, Alberto Prieto Maradona, Miguel Saarela, Maria Wallace, Robert John Anguita, Montserrat Pettenati, Elisa Tarrés‐Call, Jordi Ramos, Fernando EFSA J Scientific Opinion Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 when used as a nutritional additive in feed and water for drinking for all animal species. The active substance is l‐lysine and it is produced in two different forms (monohydrochloride or sulfate salts). None of those forms pose any safety concern associated with the genetic modification of the production strain. l‐Lysine HCl and l‐lysine sulfate produced by C. glutamicum CGMCC 7.266 are considered safe for the target species, for the consumer and for the environment. For both products, the FEEDAP Panel has concerns regarding the safety for the target species when the additives are administered via feed and water for drinking, simultaneously. In the absence of data, the FEEDAP Panel cannot conclude on the safety of both forms of the additive for the user. The products under assessment are considered efficacious sources of the amino acid l‐lysine for all animal species. For these products to be as efficacious in ruminants as in non‐ruminant species, they require protection against degradation in the rumen. John Wiley and Sons Inc. 2020-02-24 /pmc/articles/PMC7447873/ /pubmed/32874228 http://dx.doi.org/10.2903/j.efsa.2020.6019 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Dierick, Noël
Glandorf, Boet
Herman, Lieve
Mantovani, Alberto
Prieto Maradona, Miguel
Saarela, Maria
Wallace, Robert John
Anguita, Montserrat
Pettenati, Elisa
Tarrés‐Call, Jordi
Ramos, Fernando
Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species
title Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species
title_full Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species
title_fullStr Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species
title_full_unstemmed Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species
title_short Safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using Corynebacterium glutamicum CGMCC 7.266 for all animal species
title_sort safety and efficacy of l‐lysine monohydrochloride and l‐lysine sulfate produced using corynebacterium glutamicum cgmcc 7.266 for all animal species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447873/
https://www.ncbi.nlm.nih.gov/pubmed/32874228
http://dx.doi.org/10.2903/j.efsa.2020.6019
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