Cargando…
Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans
The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 and cDC2. In humans, cDC2-related subsets have...
Autores principales: | Cytlak, Urszula, Resteu, Anastasia, Pagan, Sarah, Green, Kile, Milne, Paul, Maisuria, Sheetal, McDonald, David, Hulme, Gillian, Filby, Andrew, Carpenter, Benjamin, Queen, Rachel, Hambleton, Sophie, Hague, Rosie, Lango Allen, Hana, Thaventhiran, James E.D., Doody, Gina, Collin, Matthew, Bigley, Venetia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447982/ https://www.ncbi.nlm.nih.gov/pubmed/32735845 http://dx.doi.org/10.1016/j.immuni.2020.07.003 |
Ejemplares similares
-
Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation
por: Bigley, Venetia, et al.
Publicado: (2018) -
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells
por: Kirkling, Margaret E., et al.
Publicado: (2018) -
Ikaros family zinc finger 1 regulates dendritic cell development and function in humans
por: Cytlak, Urszula, et al.
Publicado: (2018) -
Targeted treatment of brainstem neurohistiocytosis guided by urinary cell-free DNA
por: Hunt, David, et al.
Publicado: (2016) -
Langerin-expressing dendritic cells in human tissues are related to
CD1c(+) dendritic cells and distinct from Langerhans cells and
CD141(high) XCR1(+) dendritic cells
por: Bigley, Venetia, et al.
Publicado: (2015)