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Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)
The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure–Activity Relationship (QSA...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447991/ https://www.ncbi.nlm.nih.gov/pubmed/32874265 http://dx.doi.org/10.2903/j.efsa.2020.6053 |
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| author | Hernandez‐Jerez, Antonio F Adriaanse, Paulien Aldrich, Annette Berny, Philippe Coja, Tamara Duquesne, Sabine Gimsing, Anne Louise Marinovich, Marina Millet, Maurice Pelkonen, Olavi Pieper, Silvia Tiktak, Aaldrik Topping, Christopher J Tzoulaki, Ioanna Widenfalk, Anneli Wolterink, Gerrit Benford, Diane Aquilina, Gabriele Bignami, Margherita Bolognesi, Claudia Crebelli, Riccardo Guertler, Rainer Marcon, Francesca Nielsen, Elsa Schlatter, Josef Rudolf Vleminckx, Christiane Maurici, Daniela Parra Morte, Juan Manuel |
| author_facet | Hernandez‐Jerez, Antonio F Adriaanse, Paulien Aldrich, Annette Berny, Philippe Coja, Tamara Duquesne, Sabine Gimsing, Anne Louise Marinovich, Marina Millet, Maurice Pelkonen, Olavi Pieper, Silvia Tiktak, Aaldrik Topping, Christopher J Tzoulaki, Ioanna Widenfalk, Anneli Wolterink, Gerrit Benford, Diane Aquilina, Gabriele Bignami, Margherita Bolognesi, Claudia Crebelli, Riccardo Guertler, Rainer Marcon, Francesca Nielsen, Elsa Schlatter, Josef Rudolf Vleminckx, Christiane Maurici, Daniela Parra Morte, Juan Manuel |
| collection | PubMed |
| description | The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure–Activity Relationship (QSAR) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross‐cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. For a conclusion, an in vitro micronucleus assay performed with triazine amine would be needed. |
| format | Online Article Text |
| id | pubmed-7447991 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74479912020-08-31 Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) Hernandez‐Jerez, Antonio F Adriaanse, Paulien Aldrich, Annette Berny, Philippe Coja, Tamara Duquesne, Sabine Gimsing, Anne Louise Marinovich, Marina Millet, Maurice Pelkonen, Olavi Pieper, Silvia Tiktak, Aaldrik Topping, Christopher J Tzoulaki, Ioanna Widenfalk, Anneli Wolterink, Gerrit Benford, Diane Aquilina, Gabriele Bignami, Margherita Bolognesi, Claudia Crebelli, Riccardo Guertler, Rainer Marcon, Francesca Nielsen, Elsa Schlatter, Josef Rudolf Vleminckx, Christiane Maurici, Daniela Parra Morte, Juan Manuel EFSA J Scientific Opinion The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure–Activity Relationship (QSAR) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross‐cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. For a conclusion, an in vitro micronucleus assay performed with triazine amine would be needed. John Wiley and Sons Inc. 2020-03-09 /pmc/articles/PMC7447991/ /pubmed/32874265 http://dx.doi.org/10.2903/j.efsa.2020.6053 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
| spellingShingle | Scientific Opinion Hernandez‐Jerez, Antonio F Adriaanse, Paulien Aldrich, Annette Berny, Philippe Coja, Tamara Duquesne, Sabine Gimsing, Anne Louise Marinovich, Marina Millet, Maurice Pelkonen, Olavi Pieper, Silvia Tiktak, Aaldrik Topping, Christopher J Tzoulaki, Ioanna Widenfalk, Anneli Wolterink, Gerrit Benford, Diane Aquilina, Gabriele Bignami, Margherita Bolognesi, Claudia Crebelli, Riccardo Guertler, Rainer Marcon, Francesca Nielsen, Elsa Schlatter, Josef Rudolf Vleminckx, Christiane Maurici, Daniela Parra Morte, Juan Manuel Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| title | Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| title_full | Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| title_fullStr | Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| title_full_unstemmed | Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| title_short | Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| title_sort | scientific opinion of the scientific panel on plant protection products and their residues (ppr panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances) |
| topic | Scientific Opinion |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447991/ https://www.ncbi.nlm.nih.gov/pubmed/32874265 http://dx.doi.org/10.2903/j.efsa.2020.6053 |
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