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Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of oct‐1‐en‐3‐ol [02.023], pent‐1‐en‐3‐ol [02.099], oct‐1‐en‐3‐one [07.081], oct‐1‐en‐3‐yl acetat...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Kouba, Maryline, Kos Durjava, Mojca, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Brantom, Paul, Chesson, Andrew, Westendorf, Johannes, Gregoretti, Lucilla, Manini, Paola, Dusemund, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448000/
https://www.ncbi.nlm.nih.gov/pubmed/32874217
http://dx.doi.org/10.2903/j.efsa.2020.6002
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Kouba, Maryline
Kos Durjava, Mojca
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Chesson, Andrew
Westendorf, Johannes
Gregoretti, Lucilla
Manini, Paola
Dusemund, Birgit
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Kouba, Maryline
Kos Durjava, Mojca
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Chesson, Andrew
Westendorf, Johannes
Gregoretti, Lucilla
Manini, Paola
Dusemund, Birgit
collection PubMed
description Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of oct‐1‐en‐3‐ol [02.023], pent‐1‐en‐3‐ol [02.099], oct‐1‐en‐3‐one [07.081], oct‐1‐en‐3‐yl acetate [09.281], isopulegol [02.067] and 5‐methylhept‐2‐en‐4‐one [07.139], belonging to chemical group 5, and of isopulegone [07.067] and α‐damascone [07.134] belonging to chemical group 8, when used as feed flavourings for all animal species. They are currently authorised for use as flavours in food. The FEEDAP Panel was unable to assess the safety of isopulegone because the purity of the compound could not be established and the safety of α‐damascone [07.134] because of the inconclusive assessment of its genotoxicity. The FEEDAP Panel concluded that the use of isopulegol [02.067] is safe at the maximum proposed dose of 5 mg/kg complete feed for all animal species, except cats for which the use level of 1 mg/kg is considered safe. 5‐Methylhept‐2‐en‐4‐one [07.139] is safe at the proposed normal use levels of 1 mg/kg complete feed for all animal species. For oct‐1‐en‐3‐ol [02.023], pent‐1‐en‐3‐ol [02.099], oct‐1‐en‐3‐one [07.081] and oct‐1‐en‐3‐yl acetate [09.281], the calculated safe use level is 1 mg/kg complete feed for all animal species, except cats for which the calculated safe level is 0.6 mg/kg. No safety concern would arise for the consumer from the use of these compounds up to the highest safe levels in feed. In the absence of studies to assess the safety for the user, the FEEDAP Panel cannot conclude on the safety for the users when handling the additives. Use of the compounds in animal feed at the maximum safe level is considered safe for the environment. Since the compounds are used in food as flavourings and their function in feed is essentially the same, no demonstration of efficacy is necessary.
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spelling pubmed-74480002020-08-31 Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Kouba, Maryline Kos Durjava, Mojca López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Chesson, Andrew Westendorf, Johannes Gregoretti, Lucilla Manini, Paola Dusemund, Birgit EFSA J Scientific Opinion Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of oct‐1‐en‐3‐ol [02.023], pent‐1‐en‐3‐ol [02.099], oct‐1‐en‐3‐one [07.081], oct‐1‐en‐3‐yl acetate [09.281], isopulegol [02.067] and 5‐methylhept‐2‐en‐4‐one [07.139], belonging to chemical group 5, and of isopulegone [07.067] and α‐damascone [07.134] belonging to chemical group 8, when used as feed flavourings for all animal species. They are currently authorised for use as flavours in food. The FEEDAP Panel was unable to assess the safety of isopulegone because the purity of the compound could not be established and the safety of α‐damascone [07.134] because of the inconclusive assessment of its genotoxicity. The FEEDAP Panel concluded that the use of isopulegol [02.067] is safe at the maximum proposed dose of 5 mg/kg complete feed for all animal species, except cats for which the use level of 1 mg/kg is considered safe. 5‐Methylhept‐2‐en‐4‐one [07.139] is safe at the proposed normal use levels of 1 mg/kg complete feed for all animal species. For oct‐1‐en‐3‐ol [02.023], pent‐1‐en‐3‐ol [02.099], oct‐1‐en‐3‐one [07.081] and oct‐1‐en‐3‐yl acetate [09.281], the calculated safe use level is 1 mg/kg complete feed for all animal species, except cats for which the calculated safe level is 0.6 mg/kg. No safety concern would arise for the consumer from the use of these compounds up to the highest safe levels in feed. In the absence of studies to assess the safety for the user, the FEEDAP Panel cannot conclude on the safety for the users when handling the additives. Use of the compounds in animal feed at the maximum safe level is considered safe for the environment. Since the compounds are used in food as flavourings and their function in feed is essentially the same, no demonstration of efficacy is necessary. John Wiley and Sons Inc. 2020-02-19 /pmc/articles/PMC7448000/ /pubmed/32874217 http://dx.doi.org/10.2903/j.efsa.2020.6002 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Kouba, Maryline
Kos Durjava, Mojca
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Chesson, Andrew
Westendorf, Johannes
Gregoretti, Lucilla
Manini, Paola
Dusemund, Birgit
Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
title Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
title_full Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
title_fullStr Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
title_full_unstemmed Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
title_short Safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
title_sort safety and efficacy of oct‐1‐en‐3‐ol, pent‐1‐en‐3‐ol, oct‐1‐en‐3‐one, oct‐1‐en‐3‐yl acetate, isopulegol and 5‐methylhept‐2‐en‐4‐one, belonging to chemical group 5 and of isopulegone and α‐damascone belonging to chemical group 8 when used as flavourings for all animal species
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448000/
https://www.ncbi.nlm.nih.gov/pubmed/32874217
http://dx.doi.org/10.2903/j.efsa.2020.6002
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