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Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on OptiPhos PLUS (®) to be used as a feed additive for chickens for fattening, chickens reared for laying, turkeys for fattening,...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Kos Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Cocconcelli, Pier Sandro, Glandorf, Boet, Herman, Lieve, Prieto, Miguel Maradona, Saarela, Maria, Anguita, Montserrat, Brozzi, Rosella, Cazorla, Yolanda García, Galobart, Jaume, Holczknecht, Orsolya, Manini, Paola, Pettenati, Elisa, Tarrés‐Call, Jordi, Pizzo, Fabiola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448049/
https://www.ncbi.nlm.nih.gov/pubmed/32874322
http://dx.doi.org/10.2903/j.efsa.2020.6141
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Glandorf, Boet
Herman, Lieve
Prieto, Miguel Maradona
Saarela, Maria
Anguita, Montserrat
Brozzi, Rosella
Cazorla, Yolanda García
Galobart, Jaume
Holczknecht, Orsolya
Manini, Paola
Pettenati, Elisa
Tarrés‐Call, Jordi
Pizzo, Fabiola
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Glandorf, Boet
Herman, Lieve
Prieto, Miguel Maradona
Saarela, Maria
Anguita, Montserrat
Brozzi, Rosella
Cazorla, Yolanda García
Galobart, Jaume
Holczknecht, Orsolya
Manini, Paola
Pettenati, Elisa
Tarrés‐Call, Jordi
Pizzo, Fabiola
collection PubMed
description Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on OptiPhos PLUS (®) to be used as a feed additive for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, minor poultry species for fattening, minor poultry species reared for laying, minor poultry species reared for breeding and ornamental birds. The active substance is 6‐phytase produced by a genetically modified strain of Komagataella phaffii. The FEEDAP Panel concludes that the genetic modification of the production strain does not give rise to safety concerns. Based on the tolerance studies provided, the Panel concludes that the additive is safe for the target species under the conditions of use with a wide margin of safety. The additive is not a skin irritant. It is found to be a dermal sensitiser. The FEEDAP Panel cannot conclude on the eye irritation potential of the additive. Owing to the proteinaceous nature of the active substance, the additive is considered a respiratory sensitiser. The FEEDAP Panel concludes that the additive has the potential to be efficacious in increasing the phosphorus utilisation in chickens for fattening at the level of 250 FTU/kg feed. These conclusions can be extended to turkeys for fattening and chickens and turkeys reared for laying/breeding and extrapolated to all minor poultry species and other avian species up to the point of lay.
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spelling pubmed-74480492020-08-31 Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Kos Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Cocconcelli, Pier Sandro Glandorf, Boet Herman, Lieve Prieto, Miguel Maradona Saarela, Maria Anguita, Montserrat Brozzi, Rosella Cazorla, Yolanda García Galobart, Jaume Holczknecht, Orsolya Manini, Paola Pettenati, Elisa Tarrés‐Call, Jordi Pizzo, Fabiola EFSA J Scientific Opinion Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on OptiPhos PLUS (®) to be used as a feed additive for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, minor poultry species for fattening, minor poultry species reared for laying, minor poultry species reared for breeding and ornamental birds. The active substance is 6‐phytase produced by a genetically modified strain of Komagataella phaffii. The FEEDAP Panel concludes that the genetic modification of the production strain does not give rise to safety concerns. Based on the tolerance studies provided, the Panel concludes that the additive is safe for the target species under the conditions of use with a wide margin of safety. The additive is not a skin irritant. It is found to be a dermal sensitiser. The FEEDAP Panel cannot conclude on the eye irritation potential of the additive. Owing to the proteinaceous nature of the active substance, the additive is considered a respiratory sensitiser. The FEEDAP Panel concludes that the additive has the potential to be efficacious in increasing the phosphorus utilisation in chickens for fattening at the level of 250 FTU/kg feed. These conclusions can be extended to turkeys for fattening and chickens and turkeys reared for laying/breeding and extrapolated to all minor poultry species and other avian species up to the point of lay. John Wiley and Sons Inc. 2020-06-05 /pmc/articles/PMC7448049/ /pubmed/32874322 http://dx.doi.org/10.2903/j.efsa.2020.6141 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Cocconcelli, Pier Sandro
Glandorf, Boet
Herman, Lieve
Prieto, Miguel Maradona
Saarela, Maria
Anguita, Montserrat
Brozzi, Rosella
Cazorla, Yolanda García
Galobart, Jaume
Holczknecht, Orsolya
Manini, Paola
Pettenati, Elisa
Tarrés‐Call, Jordi
Pizzo, Fabiola
Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
title Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
title_full Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
title_fullStr Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
title_full_unstemmed Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
title_short Safety and efficacy of OptiPhos(®) PLUS for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
title_sort safety and efficacy of optiphos(®) plus for poultry species for fattening, minor poultry species reared for breeding and ornamental birds
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448049/
https://www.ncbi.nlm.nih.gov/pubmed/32874322
http://dx.doi.org/10.2903/j.efsa.2020.6141
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