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Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system

A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional altera...

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Autores principales: Craig, Peter S, Dujardin, Bruno, Hart, Andy, Hernández‐Jerez, Antonio F, Hougaard Bennekou, Susanne, Kneuer, Carsten, Ossendorp, Bernadette, Pedersen, Ragnor, Wolterink, Gerrit, Mohimont, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448057/
https://www.ncbi.nlm.nih.gov/pubmed/32874295
http://dx.doi.org/10.2903/j.efsa.2020.6087
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author Craig, Peter S
Dujardin, Bruno
Hart, Andy
Hernández‐Jerez, Antonio F
Hougaard Bennekou, Susanne
Kneuer, Carsten
Ossendorp, Bernadette
Pedersen, Ragnor
Wolterink, Gerrit
Mohimont, Luc
author_facet Craig, Peter S
Dujardin, Bruno
Hart, Andy
Hernández‐Jerez, Antonio F
Hougaard Bennekou, Susanne
Kneuer, Carsten
Ossendorp, Bernadette
Pedersen, Ragnor
Wolterink, Gerrit
Mohimont, Luc
collection PubMed
description A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations of the motor division. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system. Cumulative exposure assessments were conducted through probabilistic modelling by EFSA and the Dutch National Institute for Public Health and the Environment (RIVM) using two different software tools and reported separately. These exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual consumption data from 10 populations of consumers from different countries and different age groups. This report completes the characterisation of cumulative risk, taking account of the available data and the uncertainties involved. For each of the 10 populations, it is concluded with varying degrees of certainty that cumulative exposure to pesticides that have the acute effects on the nervous system mentioned above does not exceed the threshold for regulatory consideration established by risk managers.
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spelling pubmed-74480572020-08-31 Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system Craig, Peter S Dujardin, Bruno Hart, Andy Hernández‐Jerez, Antonio F Hougaard Bennekou, Susanne Kneuer, Carsten Ossendorp, Bernadette Pedersen, Ragnor Wolterink, Gerrit Mohimont, Luc EFSA J Scientific Report A retrospective acute cumulative risk assessment of dietary exposure to pesticide residues, supported by an uncertainty analysis based on expert knowledge elicitation, was conducted for two effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations of the motor division. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system. Cumulative exposure assessments were conducted through probabilistic modelling by EFSA and the Dutch National Institute for Public Health and the Environment (RIVM) using two different software tools and reported separately. These exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual consumption data from 10 populations of consumers from different countries and different age groups. This report completes the characterisation of cumulative risk, taking account of the available data and the uncertainties involved. For each of the 10 populations, it is concluded with varying degrees of certainty that cumulative exposure to pesticides that have the acute effects on the nervous system mentioned above does not exceed the threshold for regulatory consideration established by risk managers. John Wiley and Sons Inc. 2020-04-29 /pmc/articles/PMC7448057/ /pubmed/32874295 http://dx.doi.org/10.2903/j.efsa.2020.6087 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Report
Craig, Peter S
Dujardin, Bruno
Hart, Andy
Hernández‐Jerez, Antonio F
Hougaard Bennekou, Susanne
Kneuer, Carsten
Ossendorp, Bernadette
Pedersen, Ragnor
Wolterink, Gerrit
Mohimont, Luc
Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
title Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
title_full Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
title_fullStr Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
title_full_unstemmed Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
title_short Cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
title_sort cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system
topic Scientific Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448057/
https://www.ncbi.nlm.nih.gov/pubmed/32874295
http://dx.doi.org/10.2903/j.efsa.2020.6087
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