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Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy Nimicoat(®) (carvacrol), as a zootechnical additive for weaned piglets. The additive is composed by ca...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, de Lourdes Bastos, Maria, Christensen, Henrik, Dusemund, Birgit, Kos Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Finizio, Antonio, Focks, Andreas, Teodorovic, Ivana, Gropp, Jürgen, Mantovani, Alberto, López‐Gálvez, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448059/
https://www.ncbi.nlm.nih.gov/pubmed/32874282
http://dx.doi.org/10.2903/j.efsa.2020.6070
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author Bampidis, Vasileios
Azimonti, Giovanna
de Lourdes Bastos, Maria
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Finizio, Antonio
Focks, Andreas
Teodorovic, Ivana
Gropp, Jürgen
Mantovani, Alberto
López‐Gálvez, Gloria
author_facet Bampidis, Vasileios
Azimonti, Giovanna
de Lourdes Bastos, Maria
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Finizio, Antonio
Focks, Andreas
Teodorovic, Ivana
Gropp, Jürgen
Mantovani, Alberto
López‐Gálvez, Gloria
collection PubMed
description Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy Nimicoat(®) (carvacrol), as a zootechnical additive for weaned piglets. The additive is composed by carvacrol (≥  40 %) as an active substance encapsulated with high‐melting lipids. Nimicoat(®) is intended to be used in feed for weaned piglets at a minimum recommended dose of 250 mg/kg complete feed and at a maximum recommended dose of 1,000 mg/kg complete feed corresponding to a minimum and maximum of 100 and 400 mg carvacrol/kg complete feed, respectively. Based on a tolerance study, the FEEDAP Panel concluded that the use of Nimicoat(®) in feed for weaned piglet at the maximum recommended dose of 1,000 mg/kg feed is safe for the target animal; however, a precise figure for the margin of safety cannot be defined. Nimicoat(®) used in feed for weaned piglets at the maximum recommended concentration does not pose a safety concern for consumers. The additive is corrosive to eyes, skin and the respiratory mucosae. Concerning safety for the environment a Phase II was required; taking into consideration the data provided, the FEEDAP Panel concluded that the additive does not pose any risk to the terrestrial and aquatic compartments and that bioaccumulation potential for carvacrol is low and risk for secondary poisoning for worm/fish eating birds and mammals is not likely to occur. Only one study positively supporting efficacy of the additive was available; therefore, the FEEDAP Panel is not in a position to conclude on the efficacy of Nimicoat(®).
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spelling pubmed-74480592020-08-31 Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets Bampidis, Vasileios Azimonti, Giovanna de Lourdes Bastos, Maria Christensen, Henrik Dusemund, Birgit Kos Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Finizio, Antonio Focks, Andreas Teodorovic, Ivana Gropp, Jürgen Mantovani, Alberto López‐Gálvez, Gloria EFSA J Scientific Opinion Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy Nimicoat(®) (carvacrol), as a zootechnical additive for weaned piglets. The additive is composed by carvacrol (≥  40 %) as an active substance encapsulated with high‐melting lipids. Nimicoat(®) is intended to be used in feed for weaned piglets at a minimum recommended dose of 250 mg/kg complete feed and at a maximum recommended dose of 1,000 mg/kg complete feed corresponding to a minimum and maximum of 100 and 400 mg carvacrol/kg complete feed, respectively. Based on a tolerance study, the FEEDAP Panel concluded that the use of Nimicoat(®) in feed for weaned piglet at the maximum recommended dose of 1,000 mg/kg feed is safe for the target animal; however, a precise figure for the margin of safety cannot be defined. Nimicoat(®) used in feed for weaned piglets at the maximum recommended concentration does not pose a safety concern for consumers. The additive is corrosive to eyes, skin and the respiratory mucosae. Concerning safety for the environment a Phase II was required; taking into consideration the data provided, the FEEDAP Panel concluded that the additive does not pose any risk to the terrestrial and aquatic compartments and that bioaccumulation potential for carvacrol is low and risk for secondary poisoning for worm/fish eating birds and mammals is not likely to occur. Only one study positively supporting efficacy of the additive was available; therefore, the FEEDAP Panel is not in a position to conclude on the efficacy of Nimicoat(®). John Wiley and Sons Inc. 2020-04-21 /pmc/articles/PMC7448059/ /pubmed/32874282 http://dx.doi.org/10.2903/j.efsa.2020.6070 Text en © 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
de Lourdes Bastos, Maria
Christensen, Henrik
Dusemund, Birgit
Kos Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Finizio, Antonio
Focks, Andreas
Teodorovic, Ivana
Gropp, Jürgen
Mantovani, Alberto
López‐Gálvez, Gloria
Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
title Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
title_full Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
title_fullStr Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
title_full_unstemmed Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
title_short Safety and efficacy of Nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
title_sort safety and efficacy of nimicoat(®) (carvacrol) as a zootechnical additive for weaned piglets
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448059/
https://www.ncbi.nlm.nih.gov/pubmed/32874282
http://dx.doi.org/10.2903/j.efsa.2020.6070
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