Cargando…

Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus

BACKGROUND: Osseous cyst echinococcosis (CE) is an infectious disease that causes disability and deformity in patients, yet there is still no satisfactory treatment. Focusing on the feasibility and prognosis of radiotherapy as an adjuvant or palliative treatment for osseous CE, this study investigat...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Chao, Luo, Xuefeng, Mahan, Wuluhan, Tang, Yahui, Duan, Yun, Mao, Rui, Xie, Zengru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448241/
https://www.ncbi.nlm.nih.gov/pubmed/32879885
http://dx.doi.org/10.1155/2020/6457419
_version_ 1783574462337122304
author Ma, Chao
Luo, Xuefeng
Mahan, Wuluhan
Tang, Yahui
Duan, Yun
Mao, Rui
Xie, Zengru
author_facet Ma, Chao
Luo, Xuefeng
Mahan, Wuluhan
Tang, Yahui
Duan, Yun
Mao, Rui
Xie, Zengru
author_sort Ma, Chao
collection PubMed
description BACKGROUND: Osseous cyst echinococcosis (CE) is an infectious disease that causes disability and deformity in patients, yet there is still no satisfactory treatment. Focusing on the feasibility and prognosis of radiotherapy as an adjuvant or palliative treatment for osseous CE, this study investigated the outcome of Meriones meridianus with osseous CE after radiotherapy. METHODS: The study utilized a comparison control group design with three groups of gerbils, and 240 osseous CE gerbils were randomly divided into control, 40Gy/5times, and 50Gy/5times groups. Different doses of radiotherapy were given to the gerbils, and then, the effects of radiotherapy on gerbils and lesions were observed at 3 and 6 months after radiotherapy. Statistical analysis was done using χ(2) test, unpaired t-test, and one-way ANOVA. RESULTS: Significant changes (P < 0.05) were achieved between the three groups in terms of seven parameters at 3 and 6 months, including the number of dead gerbils and lesion sites with ulceration and infection, number of dead scolices, protein content, Ca2+ concentration, the maximum diameter of lesion site, and wet weight of cysts. Except for the number of dead gerbils and lesion sites with ulceration and infection, all other parameters were observed a big difference between 3 months and 6 months in the 50Gy/5times group. CONCLUSION: Radiotherapy at a dose of 50 Gy has inhibitory and therapeutic effects on osseous CE in gerbils, and radiotherapy could probably be a treatment option for persistent or recurrent osseous CE.
format Online
Article
Text
id pubmed-7448241
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-74482412020-09-01 Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus Ma, Chao Luo, Xuefeng Mahan, Wuluhan Tang, Yahui Duan, Yun Mao, Rui Xie, Zengru Biomed Res Int Research Article BACKGROUND: Osseous cyst echinococcosis (CE) is an infectious disease that causes disability and deformity in patients, yet there is still no satisfactory treatment. Focusing on the feasibility and prognosis of radiotherapy as an adjuvant or palliative treatment for osseous CE, this study investigated the outcome of Meriones meridianus with osseous CE after radiotherapy. METHODS: The study utilized a comparison control group design with three groups of gerbils, and 240 osseous CE gerbils were randomly divided into control, 40Gy/5times, and 50Gy/5times groups. Different doses of radiotherapy were given to the gerbils, and then, the effects of radiotherapy on gerbils and lesions were observed at 3 and 6 months after radiotherapy. Statistical analysis was done using χ(2) test, unpaired t-test, and one-way ANOVA. RESULTS: Significant changes (P < 0.05) were achieved between the three groups in terms of seven parameters at 3 and 6 months, including the number of dead gerbils and lesion sites with ulceration and infection, number of dead scolices, protein content, Ca2+ concentration, the maximum diameter of lesion site, and wet weight of cysts. Except for the number of dead gerbils and lesion sites with ulceration and infection, all other parameters were observed a big difference between 3 months and 6 months in the 50Gy/5times group. CONCLUSION: Radiotherapy at a dose of 50 Gy has inhibitory and therapeutic effects on osseous CE in gerbils, and radiotherapy could probably be a treatment option for persistent or recurrent osseous CE. Hindawi 2020-08-15 /pmc/articles/PMC7448241/ /pubmed/32879885 http://dx.doi.org/10.1155/2020/6457419 Text en Copyright © 2020 Chao Ma et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ma, Chao
Luo, Xuefeng
Mahan, Wuluhan
Tang, Yahui
Duan, Yun
Mao, Rui
Xie, Zengru
Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
title Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
title_full Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
title_fullStr Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
title_full_unstemmed Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
title_short Outcomes of Radiotherapy for Osseous Echinococcosis of Meriones meridianus
title_sort outcomes of radiotherapy for osseous echinococcosis of meriones meridianus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448241/
https://www.ncbi.nlm.nih.gov/pubmed/32879885
http://dx.doi.org/10.1155/2020/6457419
work_keys_str_mv AT machao outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus
AT luoxuefeng outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus
AT mahanwuluhan outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus
AT tangyahui outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus
AT duanyun outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus
AT maorui outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus
AT xiezengru outcomesofradiotherapyforosseousechinococcosisofmerionesmeridianus