Cargando…

Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways

Dihydroartemisinin (DHA), an active metabolite and derivative of artemisinin, is the most effective antimalarial drug and has strong antitumor activity in various tumor types. It has recently been reported that DHA can induce autophagy and has significant effects on multiple myeloma (MM), but the me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xiuhua, Liu, Yang, Zhang, Enfan, Chen, Jing, Huang, Xi, Yan, Haimeng, Cao, Wen, Qu, Jianwei, Gu, Huiyao, Xu, Ruyi, He, Jingsong, Cai, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448255/ https://www.ncbi.nlm.nih.gov/pubmed/32879652 http://dx.doi.org/10.1155/2020/6096391

Ejemplares similares

Metabolic reprogramming in macrophage responses
por: Liu, Yang, et al.
Publicado: (2021)

Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis
por: Liu, Yang, et al.
Publicado: (2022)

RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways
por: Qu, Jianwei, et al.
Publicado: (2021)

CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
por: Xu, Ruyi, et al.
Publicado: (2019)

Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis
por: Yan, Haimeng, et al.
Publicado: (2019)

The NEDD4‐1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma
por: Huang, Xi, et al.
Publicado: (2019)

NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma
por: Huang, Xi, et al.
Publicado: (2022)

Role of Wnt/β-catenin pathway in inducing autophagy and apoptosis in multiple myeloma cells
por: Su, Nan, et al.
Publicado: (2016)

Chidamide and venetoclax synergistically exert cytotoxicity on multiple myeloma by upregulating BIM expression
por: Cao, Liqin, et al.
Publicado: (2022)

TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy
por: Chen, Jing, et al.
Publicado: (2023)

Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease
por: He, Jingsong, et al.
Publicado: (2018)

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
por: Qu, Jianwei, et al.
Publicado: (2022)

How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?
por: Xu, Ruyi, et al.
Publicado: (2020)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer
por: Ma, Yanmei, et al.
Publicado: (2021)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer
por: Ma, Yanmei, et al.
Publicado: (2022)

Alisertib promotes apoptosis and autophagy in melanoma through p38 MAPK-mediated aurora a signaling
por: Shang, Yuan-Yuan, et al.
Publicado: (2017)

Dihydroartemisinin Promotes the Osteogenesis of Human Mesenchymal Stem Cells via the ERK and Wnt/β-Catenin Signaling Pathways
por: Ni, Licheng, et al.
Publicado: (2019)

Effect of bortezomib on proliferation and apoptosis of myeloma cells by activating Wnt/β-catenin signaling pathway
por: Dai, Yanling, et al.
Publicado: (2020)

Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells
por: Xu, Fang, et al.
Publicado: (2020)

Interleukin-32α promotes the proliferation of multiple myeloma cells by inducing production of IL-6 in bone marrow stromal cells
por: Lin, Xuanru, et al.
Publicado: (2017)

RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway
por: Xu, Yang, et al.
Publicado: (2020)

Wnt/β-catenin signaling pathway regulates asthma airway remodeling by influencing the expression of c-Myc and cyclin D1 via the p38 MAPK-dependent pathway
por: Jia, Xiao-Xiao, et al.
Publicado: (2019)

Integrated bioinformatic analysis of HNF1A in human cancers
por: Zhang, Enfan, et al.
Publicado: (2021)

Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis
por: Hu, Ying-Jie, et al.
Publicado: (2018)

Quercetin induces cell apoptosis of myeloma and displays a synergistic effect with dexamethasone in vitro and in vivo xenograft models
por: He, Donghua, et al.
Publicado: (2016)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways
por: Yang, Chunmei, et al.
Publicado: (2020)

Deferoxamine Inhibits Acute Lymphoblastic Leukemia Progression through Repression of ROS/HIF-1α, Wnt/β-Catenin, and p38MAPK/ERK Pathways
por: You, Hongliang, et al.
Publicado: (2022)

Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma
por: Chen, Ying, et al.
Publicado: (2020)

ALV-J inhibits autophagy through the GADD45β/MEKK4/P38MAPK signaling pathway and mediates apoptosis following autophagy
por: Liao, Zhihong, et al.
Publicado: (2020)

Dihydroartemisinin inhibits the migration of esophageal cancer cells by inducing autophagy
por: Chen, Xiao, et al.
Publicado: (2020)

Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
por: Ma, Qiang, et al.
Publicado: (2020)

Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/β-Catenin Signaling Pathway in Glioma Cells
por: Chu, Cheng-Wei, et al.
Publicado: (2019)

Corrigendum: Dihydroartemisinin Induces Growth Arrest and Overcomes Dexamethasone Resistance in Multiple Myeloma
por: Chen, Ying, et al.
Publicado: (2021)

p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells
por: Browne, A J, et al.
Publicado: (2016)

Autophagy promotes hepatic differentiation of hepatic progenitor cells by regulating the Wnt/β-catenin signaling pathway
por: Ma, Zhenzeng, et al.
Publicado: (2019)

Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis
por: Zhang, Zili, et al.
Publicado: (2017)

Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells
por: Zhu, Qingyun, et al.
Publicado: (2020)

Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy
por: Zhang, Shuwen, et al.
Publicado: (2021)

Zoledronate promotes ECM degradation and apoptosis via Wnt/β-catenin
por: Xiao, Jialing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qrl9d95p36hf9h8nlu98riplpn