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The diverse roles of RIP kinases in host-pathogen interactions
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction inclu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448748/ https://www.ncbi.nlm.nih.gov/pubmed/32859501 http://dx.doi.org/10.1016/j.semcdb.2020.08.005 |
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author | Eng, Vik Ven Wemyss, Madeleine A. Pearson, Jaclyn S. |
author_facet | Eng, Vik Ven Wemyss, Madeleine A. Pearson, Jaclyn S. |
author_sort | Eng, Vik Ven |
collection | PubMed |
description | Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms. In this review, we discuss the role of each RIPK in host responses to bacterial and viral pathogens, with a focus on studies that have used pathogen infection models rather than artificial stimulation with purified pathogen associated molecular patterns. We also discuss the intricate mechanisms of host evasion by pathogens that specifically target RIPKs for inactivation, and finally, we will touch on the controversial issue of drug development for kinase inhibitors to treat chronic inflammatory and neurological disorders, and the implications this may have on the outcome of pathogen infections. |
format | Online Article Text |
id | pubmed-7448748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74487482020-08-27 The diverse roles of RIP kinases in host-pathogen interactions Eng, Vik Ven Wemyss, Madeleine A. Pearson, Jaclyn S. Semin Cell Dev Biol Review Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key mediators of intracellular signal transduction including inflammation, autophagy and programmed cell death, and are thus essential for the early control of many diverse pathogenic organisms. In this review, we discuss the role of each RIPK in host responses to bacterial and viral pathogens, with a focus on studies that have used pathogen infection models rather than artificial stimulation with purified pathogen associated molecular patterns. We also discuss the intricate mechanisms of host evasion by pathogens that specifically target RIPKs for inactivation, and finally, we will touch on the controversial issue of drug development for kinase inhibitors to treat chronic inflammatory and neurological disorders, and the implications this may have on the outcome of pathogen infections. Published by Elsevier Ltd. 2021-01 2020-08-26 /pmc/articles/PMC7448748/ /pubmed/32859501 http://dx.doi.org/10.1016/j.semcdb.2020.08.005 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Eng, Vik Ven Wemyss, Madeleine A. Pearson, Jaclyn S. The diverse roles of RIP kinases in host-pathogen interactions |
title | The diverse roles of RIP kinases in host-pathogen interactions |
title_full | The diverse roles of RIP kinases in host-pathogen interactions |
title_fullStr | The diverse roles of RIP kinases in host-pathogen interactions |
title_full_unstemmed | The diverse roles of RIP kinases in host-pathogen interactions |
title_short | The diverse roles of RIP kinases in host-pathogen interactions |
title_sort | diverse roles of rip kinases in host-pathogen interactions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448748/ https://www.ncbi.nlm.nih.gov/pubmed/32859501 http://dx.doi.org/10.1016/j.semcdb.2020.08.005 |
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