Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance

•To date most reports on COVID-19 associated coagulopathy focused an increased activation of the plasmatic coagulation system. •Using a novel method to assess clot lysis we observed abnormalities in fibrinolysis in COVID-19 infection. •Our finding suggests that fibrinolysis system may contribute to...

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Detalles Bibliográficos
Autores principales: Bakchoul, Tamam, Hammer, Stefanie, Lang, Peter, Rosenberger, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448880/
http://dx.doi.org/10.1016/j.tru.2020.100008
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author Bakchoul, Tamam
Hammer, Stefanie
Lang, Peter
Rosenberger, Peter
author_facet Bakchoul, Tamam
Hammer, Stefanie
Lang, Peter
Rosenberger, Peter
author_sort Bakchoul, Tamam
collection PubMed
description •To date most reports on COVID-19 associated coagulopathy focused an increased activation of the plasmatic coagulation system. •Using a novel method to assess clot lysis we observed abnormalities in fibrinolysis in COVID-19 infection. •Our finding suggests that fibrinolysis system may contribute to the procoagulatory status in COVID-19 patients.
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spelling pubmed-74488802020-08-27 Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance Bakchoul, Tamam Hammer, Stefanie Lang, Peter Rosenberger, Peter Thrombosis Update Article •To date most reports on COVID-19 associated coagulopathy focused an increased activation of the plasmatic coagulation system. •Using a novel method to assess clot lysis we observed abnormalities in fibrinolysis in COVID-19 infection. •Our finding suggests that fibrinolysis system may contribute to the procoagulatory status in COVID-19 patients. The Author(s). Published by Elsevier Ltd. 2020-12 2020-08-26 /pmc/articles/PMC7448880/ http://dx.doi.org/10.1016/j.tru.2020.100008 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bakchoul, Tamam
Hammer, Stefanie
Lang, Peter
Rosenberger, Peter
Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
title Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
title_full Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
title_fullStr Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
title_full_unstemmed Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
title_short Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
title_sort fibrinolysis shut down in covid-19 patients: report on two severe cases with potential diagnostic and clinical relevance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448880/
http://dx.doi.org/10.1016/j.tru.2020.100008
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