CRISPR-based platform for carbapenemases and emerging viruses detection using Cas12a (Cpf1) effector nuclease

CRISPR-Cas12a (also called Cpf1) has been commonly used for genomic editing, based on its ability to generate precise double-stranded DNA (dsDNA) breaks. Recently, it was demonstrated that Cas12a exhibits unspecific ssDNAse activity upon target recognition. This feature allows CRISPR-Cas to be coupl...

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Detalles Bibliográficos
Autores principales: Curti, Lucia Ana, Pereyra-Bonnet, Federico, Repizo, Guillermo Daniel, Fay, Jessica Vannina, Salvatierra, Karina, Blariza, María José, Ibañez-Alegre, Daiana, Rinflerch, Adriana Raquel, Miretti, Marcos, Gimenez, Carla Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448918/
https://www.ncbi.nlm.nih.gov/pubmed/32486913
http://dx.doi.org/10.1080/22221751.2020.1763857

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