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Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV
Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles multivalently displaying critical regions of the MERS-CoV spike protein ─fusion peptide, heptad repeat 2,...
Autores principales: | Okba, Nisreen M. A., Widjaja, Ivy, van Dieren, Brenda, Aebischer, Andrea, van Amerongen, Geert, de Waal, Leon, Stittelaar, Koert J., Schipper, Debby, Martina, Byron, van den Brand, Judith M. A., Beer, Martin, Bosch, Berend-Jan, Haagmans, Bart L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448924/ https://www.ncbi.nlm.nih.gov/pubmed/32471334 http://dx.doi.org/10.1080/22221751.2020.1760735 |
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