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The association between FTO genotype with macronutrients and calorie intake in overweight adults

BACKGROUND: Dietary macronutrients may indirectly affect body weight through their interactions with the fat mass and obesity associated (FTO) gene. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macronutrients intake in overweight adults. METHODS: This...

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Autores principales: Mehrdad, Mahsa, Doaei, Saeid, Gholamalizadeh, Maryam, Eftekhari, Mohammad Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449073/
https://www.ncbi.nlm.nih.gov/pubmed/32843047
http://dx.doi.org/10.1186/s12944-020-01372-x
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author Mehrdad, Mahsa
Doaei, Saeid
Gholamalizadeh, Maryam
Eftekhari, Mohammad Hassan
author_facet Mehrdad, Mahsa
Doaei, Saeid
Gholamalizadeh, Maryam
Eftekhari, Mohammad Hassan
author_sort Mehrdad, Mahsa
collection PubMed
description BACKGROUND: Dietary macronutrients may indirectly affect body weight through their interactions with the fat mass and obesity associated (FTO) gene. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macronutrients intake in overweight adults. METHODS: This study was carried out on 196 overweight adults of Shiraz, Iran. Dietary intake was assessed using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. The association between dietary macronutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, and the serum levels of triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL). RESULTS: The higher intake of carbohydrates (P < 0.001), fat (P = 0.009), and calorie (P = 0.001) were significantly associated with rs9939609 AA genotype (P = 0.001). Carriers of the AA genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype after adjusting for age and sex (P = 0.019, P = 0.010 and P = 0.001, respectively). Further adjustments for physical activity, TG, LDL, and FBS did not change these results. CONCLUSION: The amounts of dietary calorie, carbohydrate, and fat intake were associated with FTO genotype. Further studies are warranted to confirm these associations and to identify the underlying mechanisms.
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spelling pubmed-74490732020-08-28 The association between FTO genotype with macronutrients and calorie intake in overweight adults Mehrdad, Mahsa Doaei, Saeid Gholamalizadeh, Maryam Eftekhari, Mohammad Hassan Lipids Health Dis Research BACKGROUND: Dietary macronutrients may indirectly affect body weight through their interactions with the fat mass and obesity associated (FTO) gene. This study aimed to investigate the association between FTO gene rs9939609 polymorphism with macronutrients intake in overweight adults. METHODS: This study was carried out on 196 overweight adults of Shiraz, Iran. Dietary intake was assessed using a validated 168-item semi-quantitative food frequency questionnaire (FFQ). The FTO gene was genotyped for rs9939609 polymorphism. The association between dietary macronutrients and the FTO genotype were assessed using linear regression after adjustments for sex, age, physical activity, and the serum levels of triglycerides, fasting blood sugar (FBS), and low density lipoprotein (LDL). RESULTS: The higher intake of carbohydrates (P < 0.001), fat (P = 0.009), and calorie (P = 0.001) were significantly associated with rs9939609 AA genotype (P = 0.001). Carriers of the AA genotype of rs9939609 had significantly higher calorie, fat, and carbohydrate intake than the carriers of the TT genotype after adjusting for age and sex (P = 0.019, P = 0.010 and P = 0.001, respectively). Further adjustments for physical activity, TG, LDL, and FBS did not change these results. CONCLUSION: The amounts of dietary calorie, carbohydrate, and fat intake were associated with FTO genotype. Further studies are warranted to confirm these associations and to identify the underlying mechanisms. BioMed Central 2020-08-26 /pmc/articles/PMC7449073/ /pubmed/32843047 http://dx.doi.org/10.1186/s12944-020-01372-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Mehrdad, Mahsa
Doaei, Saeid
Gholamalizadeh, Maryam
Eftekhari, Mohammad Hassan
The association between FTO genotype with macronutrients and calorie intake in overweight adults
title The association between FTO genotype with macronutrients and calorie intake in overweight adults
title_full The association between FTO genotype with macronutrients and calorie intake in overweight adults
title_fullStr The association between FTO genotype with macronutrients and calorie intake in overweight adults
title_full_unstemmed The association between FTO genotype with macronutrients and calorie intake in overweight adults
title_short The association between FTO genotype with macronutrients and calorie intake in overweight adults
title_sort association between fto genotype with macronutrients and calorie intake in overweight adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449073/
https://www.ncbi.nlm.nih.gov/pubmed/32843047
http://dx.doi.org/10.1186/s12944-020-01372-x
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