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Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk
BACKGROUND: It is important to understand how HIV infection is transmitted in the population in order to guide prevention activities and properly allocate limited resources. In Ukraine and other countries where injecting drug use and homosexuality are stigmatized, the information about mode of trans...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449084/ https://www.ncbi.nlm.nih.gov/pubmed/32843008 http://dx.doi.org/10.1186/s12889-020-09373-2 |
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author | Dumchev, Kostyantyn Kornilova, Marina Kulchynska, Roksolana Azarskova, Marianna Vitek, Charles |
author_facet | Dumchev, Kostyantyn Kornilova, Marina Kulchynska, Roksolana Azarskova, Marianna Vitek, Charles |
author_sort | Dumchev, Kostyantyn |
collection | PubMed |
description | BACKGROUND: It is important to understand how HIV infection is transmitted in the population in order to guide prevention activities and properly allocate limited resources. In Ukraine and other countries where injecting drug use and homosexuality are stigmatized, the information about mode of transmission in case registration systems is often biased. METHODS: We conducted a cross-sectional survey in a random sample of patients registered at HIV clinics in seven regions of Ukraine in 2013–2015. The survey assessed behavioral risk factors and serological markers of viral hepatitis B and C. We analyzed the discrepancies between the registered mode of transmission and the survey data, and evaluated trends over 3 years. RESULTS: Of 2285 participants, 1032 (45.2%) were females. The proportion of new HIV cases likely caused by injecting drug use based on the survey data was 59.7% compared to 33.2% in official reporting, and proportion of cases likely acquired through homosexual transmission was 3.8% compared to 2.8%. We found a significant decrease from 63.2 to 57.5% in the proportion of injecting drug use-related cases and a steep increase from 2.5 to 5.2% in homosexual transmission over 3 years. CONCLUSIONS: The study confirmed the significant degree of misclassification of HIV mode of transmission among registered cases. The role of injecting drug use in HIV transmission is gradually decreasing, but remains high. The proportion of cases related to homosexual transmission is relatively modest, but is rapidly increasing, especially in younger men. Improvements in ascertaining the risk factor information are essential to monitor the epidemic and to guide programmatic response. |
format | Online Article Text |
id | pubmed-7449084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74490842020-08-28 Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk Dumchev, Kostyantyn Kornilova, Marina Kulchynska, Roksolana Azarskova, Marianna Vitek, Charles BMC Public Health Research Article BACKGROUND: It is important to understand how HIV infection is transmitted in the population in order to guide prevention activities and properly allocate limited resources. In Ukraine and other countries where injecting drug use and homosexuality are stigmatized, the information about mode of transmission in case registration systems is often biased. METHODS: We conducted a cross-sectional survey in a random sample of patients registered at HIV clinics in seven regions of Ukraine in 2013–2015. The survey assessed behavioral risk factors and serological markers of viral hepatitis B and C. We analyzed the discrepancies between the registered mode of transmission and the survey data, and evaluated trends over 3 years. RESULTS: Of 2285 participants, 1032 (45.2%) were females. The proportion of new HIV cases likely caused by injecting drug use based on the survey data was 59.7% compared to 33.2% in official reporting, and proportion of cases likely acquired through homosexual transmission was 3.8% compared to 2.8%. We found a significant decrease from 63.2 to 57.5% in the proportion of injecting drug use-related cases and a steep increase from 2.5 to 5.2% in homosexual transmission over 3 years. CONCLUSIONS: The study confirmed the significant degree of misclassification of HIV mode of transmission among registered cases. The role of injecting drug use in HIV transmission is gradually decreasing, but remains high. The proportion of cases related to homosexual transmission is relatively modest, but is rapidly increasing, especially in younger men. Improvements in ascertaining the risk factor information are essential to monitor the epidemic and to guide programmatic response. BioMed Central 2020-08-26 /pmc/articles/PMC7449084/ /pubmed/32843008 http://dx.doi.org/10.1186/s12889-020-09373-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Dumchev, Kostyantyn Kornilova, Marina Kulchynska, Roksolana Azarskova, Marianna Vitek, Charles Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk |
title | Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk |
title_full | Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk |
title_fullStr | Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk |
title_full_unstemmed | Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk |
title_short | Improved ascertainment of modes of HIV transmission in Ukraine indicates importance of drug injecting and homosexual risk |
title_sort | improved ascertainment of modes of hiv transmission in ukraine indicates importance of drug injecting and homosexual risk |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449084/ https://www.ncbi.nlm.nih.gov/pubmed/32843008 http://dx.doi.org/10.1186/s12889-020-09373-2 |
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