A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood–brain barrier models for drug transport studies

BACKGROUND: Predictive in vitro models of the human blood–brain barrier (BBB) are essential in early drug discovery and development. Among available immortalized human brain capillary endothelial cell lines (BCECs), the hCMEC/D3 cell line has become the most widely used in vitro BBB model. However,...

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Detalles Bibliográficos
Autores principales: Gericke, Birthe, Römermann, Kerstin, Noack, Andreas, Noack, Sandra, Kronenberg, Jessica, Blasig, Ingolf Ernst, Löscher, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449095/
https://www.ncbi.nlm.nih.gov/pubmed/32843059
http://dx.doi.org/10.1186/s12987-020-00212-5

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