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Effect of Systemic Inflammatory Response to SARS-CoV-2 on Lopinavir and Hydroxychloroquine Plasma Concentrations

Coronavirus disease 2019 (COVID-19) leads to inflammatory cytokine release, which can downregulate the expression of metabolizing enzymes. This cascade affects drug concentrations in the plasma. We investigated the association between lopinavir (LPV) and hydroxychloroquine (HCQ) plasma concentration...

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Detalles Bibliográficos
Autores principales:	Marzolini, Catia, Stader, Felix, Stoeckle, Marcel, Franzeck, Fabian, Egli, Adrian, Bassetti, Stefano, Hollinger, Alexa, Osthoff, Michael, Weisser, Maja, Gebhard, Caroline E., Baettig, Veronika, Geenen, Julia, Khanna, Nina, Tschudin-Sutter, Sarah, Mueller, Daniel, Hirsch, Hans H., Battegay, Manuel, Sendi, Parham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449226/ https://www.ncbi.nlm.nih.gov/pubmed/32641296 http://dx.doi.org/10.1128/AAC.01177-20

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