SQR mediates therapeutic effects of H(2)S by targeting mitochondrial electron transport to induce mitochondrial uncoupling

Hydrogen sulfide (H(2)S) is a gasotransmitter and a potential therapeutic agent. However, molecular targets relevant to its therapeutic actions remain enigmatic. Sulfide-quinone oxidoreductase (SQR) irreversibly oxidizes H(2)S. Therefore, SQR is assumed to inhibit H(2)S signaling. We now report that...

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Detalles Bibliográficos
Autores principales: Jia, Jia, Wang, Zichuang, Zhang, Minjie, Huang, Caiyun, Song, Yanmei, Xu, Fuyou, Zhang, Jingyu, Li, Jie, He, Meijun, Li, Yuyao, Ao, Guizhen, Hong, Chengjiao, Cao, Yongjun, Chin, Y. Eugene, Hua, Zi-chun, Cheng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449675/
https://www.ncbi.nlm.nih.gov/pubmed/32923620
http://dx.doi.org/10.1126/sciadv.aaz5752

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