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Early-life environmental enrichment generates persistent individualized behavior in mice
Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cage...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449688/ https://www.ncbi.nlm.nih.gov/pubmed/32923634 http://dx.doi.org/10.1126/sciadv.abb1478 |
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author | Zocher, Sara Schilling, Susan Grzyb, Anna N. Adusumilli, Vijay S. Bogado Lopes, Jadna Günther, Sandra Overall, Rupert W. Winter, York Kempermann, Gerd |
author_facet | Zocher, Sara Schilling, Susan Grzyb, Anna N. Adusumilli, Vijay S. Bogado Lopes, Jadna Günther, Sandra Overall, Rupert W. Winter, York Kempermann, Gerd |
author_sort | Zocher, Sara |
collection | PubMed |
description | Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics. |
format | Online Article Text |
id | pubmed-7449688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74496882020-09-11 Early-life environmental enrichment generates persistent individualized behavior in mice Zocher, Sara Schilling, Susan Grzyb, Anna N. Adusumilli, Vijay S. Bogado Lopes, Jadna Günther, Sandra Overall, Rupert W. Winter, York Kempermann, Gerd Sci Adv Research Articles Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics. American Association for the Advancement of Science 2020-08-26 /pmc/articles/PMC7449688/ /pubmed/32923634 http://dx.doi.org/10.1126/sciadv.abb1478 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Zocher, Sara Schilling, Susan Grzyb, Anna N. Adusumilli, Vijay S. Bogado Lopes, Jadna Günther, Sandra Overall, Rupert W. Winter, York Kempermann, Gerd Early-life environmental enrichment generates persistent individualized behavior in mice |
title | Early-life environmental enrichment generates persistent individualized behavior in mice |
title_full | Early-life environmental enrichment generates persistent individualized behavior in mice |
title_fullStr | Early-life environmental enrichment generates persistent individualized behavior in mice |
title_full_unstemmed | Early-life environmental enrichment generates persistent individualized behavior in mice |
title_short | Early-life environmental enrichment generates persistent individualized behavior in mice |
title_sort | early-life environmental enrichment generates persistent individualized behavior in mice |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449688/ https://www.ncbi.nlm.nih.gov/pubmed/32923634 http://dx.doi.org/10.1126/sciadv.abb1478 |
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