Cargando…

Early-life environmental enrichment generates persistent individualized behavior in mice

Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cage...

Descripción completa

Detalles Bibliográficos
Autores principales: Zocher, Sara, Schilling, Susan, Grzyb, Anna N., Adusumilli, Vijay S., Bogado Lopes, Jadna, Günther, Sandra, Overall, Rupert W., Winter, York, Kempermann, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449688/
https://www.ncbi.nlm.nih.gov/pubmed/32923634
http://dx.doi.org/10.1126/sciadv.abb1478
_version_ 1783574677302542336
author Zocher, Sara
Schilling, Susan
Grzyb, Anna N.
Adusumilli, Vijay S.
Bogado Lopes, Jadna
Günther, Sandra
Overall, Rupert W.
Winter, York
Kempermann, Gerd
author_facet Zocher, Sara
Schilling, Susan
Grzyb, Anna N.
Adusumilli, Vijay S.
Bogado Lopes, Jadna
Günther, Sandra
Overall, Rupert W.
Winter, York
Kempermann, Gerd
author_sort Zocher, Sara
collection PubMed
description Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics.
format Online
Article
Text
id pubmed-7449688
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-74496882020-09-11 Early-life environmental enrichment generates persistent individualized behavior in mice Zocher, Sara Schilling, Susan Grzyb, Anna N. Adusumilli, Vijay S. Bogado Lopes, Jadna Günther, Sandra Overall, Rupert W. Winter, York Kempermann, Gerd Sci Adv Research Articles Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics. American Association for the Advancement of Science 2020-08-26 /pmc/articles/PMC7449688/ /pubmed/32923634 http://dx.doi.org/10.1126/sciadv.abb1478 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Zocher, Sara
Schilling, Susan
Grzyb, Anna N.
Adusumilli, Vijay S.
Bogado Lopes, Jadna
Günther, Sandra
Overall, Rupert W.
Winter, York
Kempermann, Gerd
Early-life environmental enrichment generates persistent individualized behavior in mice
title Early-life environmental enrichment generates persistent individualized behavior in mice
title_full Early-life environmental enrichment generates persistent individualized behavior in mice
title_fullStr Early-life environmental enrichment generates persistent individualized behavior in mice
title_full_unstemmed Early-life environmental enrichment generates persistent individualized behavior in mice
title_short Early-life environmental enrichment generates persistent individualized behavior in mice
title_sort early-life environmental enrichment generates persistent individualized behavior in mice
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449688/
https://www.ncbi.nlm.nih.gov/pubmed/32923634
http://dx.doi.org/10.1126/sciadv.abb1478
work_keys_str_mv AT zochersara earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT schillingsusan earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT grzybannan earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT adusumillivijays earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT bogadolopesjadna earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT gunthersandra earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT overallrupertw earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT winteryork earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice
AT kempermanngerd earlylifeenvironmentalenrichmentgeneratespersistentindividualizedbehaviorinmice