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Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates
Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449756/ https://www.ncbi.nlm.nih.gov/pubmed/32923073 http://dx.doi.org/10.1364/BOE.398013 |
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author | Mittal, Vinita Devitt, George Nedeljkovic, Milos Carpenter, Lewis G. Chong, Harold M. H. Wilkinson, James S. Mahajan, Sumeet Mashanovich, Goran Z. |
author_facet | Mittal, Vinita Devitt, George Nedeljkovic, Milos Carpenter, Lewis G. Chong, Harold M. H. Wilkinson, James S. Mahajan, Sumeet Mashanovich, Goran Z. |
author_sort | Mittal, Vinita |
collection | PubMed |
description | Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm(−1) (5.3–10.0 µm) spectral region. |
format | Online Article Text |
id | pubmed-7449756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-74497562020-09-11 Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates Mittal, Vinita Devitt, George Nedeljkovic, Milos Carpenter, Lewis G. Chong, Harold M. H. Wilkinson, James S. Mahajan, Sumeet Mashanovich, Goran Z. Biomed Opt Express Article Specific proteins and their aggregates form toxic amyloid plaques and neurofibrillary tangles in the brains of people suffering from neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It is important to study these conformational changes to identify and differentiate these diseases at an early stage so that timely medication is provided to patients. Mid-infrared spectroscopy can be used to monitor these changes by studying the line-shapes and the relative absorbances of amide bands present in proteins. This work focusses on the spectroscopy of the protein, Bovine Serum Albumin as an exemplar, and its aggregates using germanium on silicon waveguides in the 1900–1000 cm(−1) (5.3–10.0 µm) spectral region. Optical Society of America 2020-07-28 /pmc/articles/PMC7449756/ /pubmed/32923073 http://dx.doi.org/10.1364/BOE.398013 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. |
spellingShingle | Article Mittal, Vinita Devitt, George Nedeljkovic, Milos Carpenter, Lewis G. Chong, Harold M. H. Wilkinson, James S. Mahajan, Sumeet Mashanovich, Goran Z. Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
title | Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
title_full | Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
title_fullStr | Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
title_full_unstemmed | Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
title_short | Ge on Si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
title_sort | ge on si waveguide mid-infrared absorption spectroscopy of proteins and their aggregates |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449756/ https://www.ncbi.nlm.nih.gov/pubmed/32923073 http://dx.doi.org/10.1364/BOE.398013 |
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