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Viral disease spreading in grouped population

BACKGROUND AND OBJECTIVE: The currently active COVID-19 pandemic has increased, among others, public interest in the computational techniques enabling the study of disease-spreading processes. Thus far, numerous approaches have been used to study the development of epidemics, with special attention...

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Autor principal: Gwizdałła, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449887/
https://www.ncbi.nlm.nih.gov/pubmed/32898813
http://dx.doi.org/10.1016/j.cmpb.2020.105715
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author Gwizdałła, Tomasz
author_facet Gwizdałła, Tomasz
author_sort Gwizdałła, Tomasz
collection PubMed
description BACKGROUND AND OBJECTIVE: The currently active COVID-19 pandemic has increased, among others, public interest in the computational techniques enabling the study of disease-spreading processes. Thus far, numerous approaches have been used to study the development of epidemics, with special attention paid to the identification of crucial elements that can strengthen or weaken the dynamics of the process. The main thread of this research is associated with the use of the ordinary differential equations method. There also exist several approaches based on the analysis of flows in the Cellular Automata (CA) approach. METHODS: In this paper, we propose a new approach to disease-spread modeling. We start by creating a network that reproduces contacts between individuals in a community. This assumption makes the presented model significantly different from the ones currently dominant in the field. It also changes the approach to the act of infection. Usually, some parameters that describe the rate of new infections by taking into account those infected in the previous time slot are considered. With our model, we can individualize this process, considering each contact individually. RESULTS: The typical output from calculations of a similar type are epidemic curves. In our model, except of presenting the average curves, we show the deviations or ranges for particular results obtained in different simulation runs, which usually lead to significantly different results. This observation is the effect of the probabilistic character of the infection process, which can impact, in different runs, individuals with different significance to the community. We can also easily present the effects of different types of intervention. The effects are studied for different methods used to create the graph representing a community, which can correspond to different social bonds. CONCLUSIONS: We see the potential usefulness of the proposition in the detailed study of epidemic development for specific environments and communities. The ease of entering new parameters enables the analysis of several specific scenarios for different contagious diseases.
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spelling pubmed-74498872020-08-27 Viral disease spreading in grouped population Gwizdałła, Tomasz Comput Methods Programs Biomed Article BACKGROUND AND OBJECTIVE: The currently active COVID-19 pandemic has increased, among others, public interest in the computational techniques enabling the study of disease-spreading processes. Thus far, numerous approaches have been used to study the development of epidemics, with special attention paid to the identification of crucial elements that can strengthen or weaken the dynamics of the process. The main thread of this research is associated with the use of the ordinary differential equations method. There also exist several approaches based on the analysis of flows in the Cellular Automata (CA) approach. METHODS: In this paper, we propose a new approach to disease-spread modeling. We start by creating a network that reproduces contacts between individuals in a community. This assumption makes the presented model significantly different from the ones currently dominant in the field. It also changes the approach to the act of infection. Usually, some parameters that describe the rate of new infections by taking into account those infected in the previous time slot are considered. With our model, we can individualize this process, considering each contact individually. RESULTS: The typical output from calculations of a similar type are epidemic curves. In our model, except of presenting the average curves, we show the deviations or ranges for particular results obtained in different simulation runs, which usually lead to significantly different results. This observation is the effect of the probabilistic character of the infection process, which can impact, in different runs, individuals with different significance to the community. We can also easily present the effects of different types of intervention. The effects are studied for different methods used to create the graph representing a community, which can correspond to different social bonds. CONCLUSIONS: We see the potential usefulness of the proposition in the detailed study of epidemic development for specific environments and communities. The ease of entering new parameters enables the analysis of several specific scenarios for different contagious diseases. Elsevier B.V. 2020-12 2020-08-27 /pmc/articles/PMC7449887/ /pubmed/32898813 http://dx.doi.org/10.1016/j.cmpb.2020.105715 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gwizdałła, Tomasz
Viral disease spreading in grouped population
title Viral disease spreading in grouped population
title_full Viral disease spreading in grouped population
title_fullStr Viral disease spreading in grouped population
title_full_unstemmed Viral disease spreading in grouped population
title_short Viral disease spreading in grouped population
title_sort viral disease spreading in grouped population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449887/
https://www.ncbi.nlm.nih.gov/pubmed/32898813
http://dx.doi.org/10.1016/j.cmpb.2020.105715
work_keys_str_mv AT gwizdałłatomasz viraldiseasespreadingingroupedpopulation