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LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1

Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenes...

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Detalles Bibliográficos
Autores principales: Lin, Shuang, Zhang, Rui, Xu, Lei, Ma, Rui, Xu, Liming, Zhu, Linghua, Hu, Jian, An, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450059/
https://www.ncbi.nlm.nih.gov/pubmed/32848140
http://dx.doi.org/10.1038/s41419-020-02889-w