The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits

The transcription factor NF-ĸB is a master regulator of the innate immune response and plays a central role in inflammatory diseases by mediating the expression of pro-inflammatory cytokines. Ubiquitination-triggered proteasomal degradation of DNA-bound NF-ĸB strongly limits the expression of its ta...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitxitorena, Izaskun, Somma, Domenico, Mitchell, Jennifer P., Lepistö, Matti, Tyrchan, Christian, Smith, Emma L., Kiely, Patrick A., Walden, Helen, Keeshan, Karen, Carmody, Ruaidhrí J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450122/
https://www.ncbi.nlm.nih.gov/pubmed/32587091
http://dx.doi.org/10.1074/jbc.RA120.014113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450122/
https://www.ncbi.nlm.nih.gov/pubmed/32587091
http://dx.doi.org/10.1074/jbc.RA120.014113

Ejemplares similares