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The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers

Using the best animal models to study immune responses against specific pathogens or vaccines can dramatically accelerate our understanding. Veterinary species are well studied, particularly livestock, to reduce their disease burden. They have also proven to be powerful models, especially for zoonot...

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Autores principales: Mwangi, William, Maccari, Giuseppe, Hope, Jayne C., Entrican, Gary, Hammond, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450168/
https://www.ncbi.nlm.nih.gov/pubmed/32548865
http://dx.doi.org/10.1111/imm.13227
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author Mwangi, William
Maccari, Giuseppe
Hope, Jayne C.
Entrican, Gary
Hammond, John A.
author_facet Mwangi, William
Maccari, Giuseppe
Hope, Jayne C.
Entrican, Gary
Hammond, John A.
author_sort Mwangi, William
collection PubMed
description Using the best animal models to study immune responses against specific pathogens or vaccines can dramatically accelerate our understanding. Veterinary species are well studied, particularly livestock, to reduce their disease burden. They have also proven to be powerful models, especially for zoonotic pathogens and novel vaccination strategies. A prerequisite for any model selection is having the right quality and range of species‐specific immunological reagents. To help promote the widest possible use of veterinary species, an open access website (https://www.immunologicaltoolbox.co.uk) has been created as a central community annotated hub for veterinary immunological reagents. The website is also the portal into services offered by the UK Immunological Toolbox project that includes antibody generation, sequencing and recombinant expression. The funding for this effort is linked into sustainable sources, but ultimate success relies on community engagement to continually increase the quality and quantity of information. It is hoped that as more users and reagent owners engage, it will become an essential resource for researchers, veterinarians and clinicians alike by removing barriers that prevent the use of the most informative animal models.
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spelling pubmed-74501682020-08-31 The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers Mwangi, William Maccari, Giuseppe Hope, Jayne C. Entrican, Gary Hammond, John A. Immunology Perspective Using the best animal models to study immune responses against specific pathogens or vaccines can dramatically accelerate our understanding. Veterinary species are well studied, particularly livestock, to reduce their disease burden. They have also proven to be powerful models, especially for zoonotic pathogens and novel vaccination strategies. A prerequisite for any model selection is having the right quality and range of species‐specific immunological reagents. To help promote the widest possible use of veterinary species, an open access website (https://www.immunologicaltoolbox.co.uk) has been created as a central community annotated hub for veterinary immunological reagents. The website is also the portal into services offered by the UK Immunological Toolbox project that includes antibody generation, sequencing and recombinant expression. The funding for this effort is linked into sustainable sources, but ultimate success relies on community engagement to continually increase the quality and quantity of information. It is hoped that as more users and reagent owners engage, it will become an essential resource for researchers, veterinarians and clinicians alike by removing barriers that prevent the use of the most informative animal models. John Wiley and Sons Inc. 2020-07-29 2020-09 /pmc/articles/PMC7450168/ /pubmed/32548865 http://dx.doi.org/10.1111/imm.13227 Text en © 2020 The Authors. Immunology published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Mwangi, William
Maccari, Giuseppe
Hope, Jayne C.
Entrican, Gary
Hammond, John A.
The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers
title The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers
title_full The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers
title_fullStr The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers
title_full_unstemmed The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers
title_short The UK Veterinary Immunological Toolbox Website: promoting vaccine research by facilitating communication and removing reagent barriers
title_sort uk veterinary immunological toolbox website: promoting vaccine research by facilitating communication and removing reagent barriers
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450168/
https://www.ncbi.nlm.nih.gov/pubmed/32548865
http://dx.doi.org/10.1111/imm.13227
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