COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?

Marked ethnic variations in complications and mortality have been noted following infection with COVID-19, with Black, Asian, and minority ethnic groups (BAME) being particularly hard hit. We hypothesise that glucocorticoid resistance stemming from several intrinsic reasons such as chronic social st...

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Detalles Bibliográficos
Autores principales: Karan, Abhinav, Ali, Kabeer, Rambaran, Kirin, Del Corral, Pedro, Sakhamuri, Sateesh, Teelucksingh, Surujpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450249/
https://www.ncbi.nlm.nih.gov/pubmed/33254527
http://dx.doi.org/10.1016/j.mehy.2020.110220
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author Karan, Abhinav
Ali, Kabeer
Rambaran, Kirin
Del Corral, Pedro
Sakhamuri, Sateesh
Teelucksingh, Surujpal
author_facet Karan, Abhinav
Ali, Kabeer
Rambaran, Kirin
Del Corral, Pedro
Sakhamuri, Sateesh
Teelucksingh, Surujpal
author_sort Karan, Abhinav
collection PubMed
description Marked ethnic variations in complications and mortality have been noted following infection with COVID-19, with Black, Asian, and minority ethnic groups (BAME) being particularly hard hit. We hypothesise that glucocorticoid resistance stemming from several intrinsic reasons such as chronic social stress and lower circulating levels of Vitamin D may contribute to the exaggerated inflammatory response, more severe disease and poorer outcomes observed in BAME.
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spelling pubmed-74502492020-08-27 COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities? Karan, Abhinav Ali, Kabeer Rambaran, Kirin Del Corral, Pedro Sakhamuri, Sateesh Teelucksingh, Surujpal Med Hypotheses Article Marked ethnic variations in complications and mortality have been noted following infection with COVID-19, with Black, Asian, and minority ethnic groups (BAME) being particularly hard hit. We hypothesise that glucocorticoid resistance stemming from several intrinsic reasons such as chronic social stress and lower circulating levels of Vitamin D may contribute to the exaggerated inflammatory response, more severe disease and poorer outcomes observed in BAME. Elsevier Ltd. 2020-11 2020-08-27 /pmc/articles/PMC7450249/ /pubmed/33254527 http://dx.doi.org/10.1016/j.mehy.2020.110220 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Karan, Abhinav
Ali, Kabeer
Rambaran, Kirin
Del Corral, Pedro
Sakhamuri, Sateesh
Teelucksingh, Surujpal
COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
title COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
title_full COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
title_fullStr COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
title_full_unstemmed COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
title_short COVID-19 and ethnicity: Does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
title_sort covid-19 and ethnicity: does reduced responsiveness to glucocorticoids explain the more aggressive nature of disease among minorities?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450249/
https://www.ncbi.nlm.nih.gov/pubmed/33254527
http://dx.doi.org/10.1016/j.mehy.2020.110220
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