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COVID-19: dealing with a potential risk factor for chronic neurological disorders

SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute respiratory distress syndrome. Occurrence of acute and subacute neurological manifestations (encephalitis, stroke, headache, seizures,...

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Autores principales: Schirinzi, Tommaso, Landi, Doriana, Liguori, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450256/
https://www.ncbi.nlm.nih.gov/pubmed/32852580
http://dx.doi.org/10.1007/s00415-020-10131-y
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author Schirinzi, Tommaso
Landi, Doriana
Liguori, Claudio
author_facet Schirinzi, Tommaso
Landi, Doriana
Liguori, Claudio
author_sort Schirinzi, Tommaso
collection PubMed
description SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute respiratory distress syndrome. Occurrence of acute and subacute neurological manifestations (encephalitis, stroke, headache, seizures, Guillain–Barrè syndrome) is increasingly reported in patients with COVID-19. Moreover, SARS-CoV2 immunopathology and tissue colonization in the gut and the central nervous system, and the systemic inflammatory response during COVID-19 may potentially trigger chronic autoimmune and neurodegenerative disorders. Specifically, Parkinson’s disease, multiple sclerosis and narcolepsy present several pathogenic mechanisms that can be hypothetically initiated by SARS-CoV2 infection in susceptible individuals. In this short narrative review, we summarize the clinical evidence supporting the rationale for investigating SARS-CoV2 infection as risk factor for these neurological disorders, and suggest the opportunity to perform in the future SARS-CoV2 serology when diagnosing these disorders.
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spelling pubmed-74502562020-08-27 COVID-19: dealing with a potential risk factor for chronic neurological disorders Schirinzi, Tommaso Landi, Doriana Liguori, Claudio J Neurol Review SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute respiratory distress syndrome. Occurrence of acute and subacute neurological manifestations (encephalitis, stroke, headache, seizures, Guillain–Barrè syndrome) is increasingly reported in patients with COVID-19. Moreover, SARS-CoV2 immunopathology and tissue colonization in the gut and the central nervous system, and the systemic inflammatory response during COVID-19 may potentially trigger chronic autoimmune and neurodegenerative disorders. Specifically, Parkinson’s disease, multiple sclerosis and narcolepsy present several pathogenic mechanisms that can be hypothetically initiated by SARS-CoV2 infection in susceptible individuals. In this short narrative review, we summarize the clinical evidence supporting the rationale for investigating SARS-CoV2 infection as risk factor for these neurological disorders, and suggest the opportunity to perform in the future SARS-CoV2 serology when diagnosing these disorders. Springer Berlin Heidelberg 2020-08-27 2021 /pmc/articles/PMC7450256/ /pubmed/32852580 http://dx.doi.org/10.1007/s00415-020-10131-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Schirinzi, Tommaso
Landi, Doriana
Liguori, Claudio
COVID-19: dealing with a potential risk factor for chronic neurological disorders
title COVID-19: dealing with a potential risk factor for chronic neurological disorders
title_full COVID-19: dealing with a potential risk factor for chronic neurological disorders
title_fullStr COVID-19: dealing with a potential risk factor for chronic neurological disorders
title_full_unstemmed COVID-19: dealing with a potential risk factor for chronic neurological disorders
title_short COVID-19: dealing with a potential risk factor for chronic neurological disorders
title_sort covid-19: dealing with a potential risk factor for chronic neurological disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450256/
https://www.ncbi.nlm.nih.gov/pubmed/32852580
http://dx.doi.org/10.1007/s00415-020-10131-y
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