The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act a...

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Autores principales: Ariston Gabriel, Abakundana Nsenga, Wang, Fang, Jiao, Qinlian, Yvette, Umwali, Yang, Xuemei, Al-Ameri, Samed Ahmed, Du, Lutao, Wang, Yun-shan, Wang, Chuanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450552/
https://www.ncbi.nlm.nih.gov/pubmed/32854710
http://dx.doi.org/10.1186/s12943-020-01245-y
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author Ariston Gabriel, Abakundana Nsenga
Wang, Fang
Jiao, Qinlian
Yvette, Umwali
Yang, Xuemei
Al-Ameri, Samed Ahmed
Du, Lutao
Wang, Yun-shan
Wang, Chuanxin
author_facet Ariston Gabriel, Abakundana Nsenga
Wang, Fang
Jiao, Qinlian
Yvette, Umwali
Yang, Xuemei
Al-Ameri, Samed Ahmed
Du, Lutao
Wang, Yun-shan
Wang, Chuanxin
author_sort Ariston Gabriel, Abakundana Nsenga
collection PubMed
description At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer.
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spelling pubmed-74505522020-08-28 The involvement of exosomes in the diagnosis and treatment of pancreatic cancer Ariston Gabriel, Abakundana Nsenga Wang, Fang Jiao, Qinlian Yvette, Umwali Yang, Xuemei Al-Ameri, Samed Ahmed Du, Lutao Wang, Yun-shan Wang, Chuanxin Mol Cancer Review At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer. BioMed Central 2020-08-27 /pmc/articles/PMC7450552/ /pubmed/32854710 http://dx.doi.org/10.1186/s12943-020-01245-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Ariston Gabriel, Abakundana Nsenga
Wang, Fang
Jiao, Qinlian
Yvette, Umwali
Yang, Xuemei
Al-Ameri, Samed Ahmed
Du, Lutao
Wang, Yun-shan
Wang, Chuanxin
The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
title The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
title_full The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
title_fullStr The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
title_full_unstemmed The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
title_short The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
title_sort involvement of exosomes in the diagnosis and treatment of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450552/
https://www.ncbi.nlm.nih.gov/pubmed/32854710
http://dx.doi.org/10.1186/s12943-020-01245-y
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