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IRONSperm: Sperm-templated soft magnetic microrobots
We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450605/ https://www.ncbi.nlm.nih.gov/pubmed/32923590 http://dx.doi.org/10.1126/sciadv.aba5855 |
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author | Magdanz, Veronika Khalil, Islam S. M. Simmchen, Juliane Furtado, Guilherme P. Mohanty, Sumit Gebauer, Johannes Xu, Haifeng Klingner, Anke Aziz, Azaam Medina-Sánchez, Mariana Schmidt, Oliver G. Misra, Sarthak |
author_facet | Magdanz, Veronika Khalil, Islam S. M. Simmchen, Juliane Furtado, Guilherme P. Mohanty, Sumit Gebauer, Johannes Xu, Haifeng Klingner, Anke Aziz, Azaam Medina-Sánchez, Mariana Schmidt, Oliver G. Misra, Sarthak |
author_sort | Magdanz, Veronika |
collection | PubMed |
description | We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy. |
format | Online Article Text |
id | pubmed-7450605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74506052020-09-11 IRONSperm: Sperm-templated soft magnetic microrobots Magdanz, Veronika Khalil, Islam S. M. Simmchen, Juliane Furtado, Guilherme P. Mohanty, Sumit Gebauer, Johannes Xu, Haifeng Klingner, Anke Aziz, Azaam Medina-Sánchez, Mariana Schmidt, Oliver G. Misra, Sarthak Sci Adv Research Articles We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy. American Association for the Advancement of Science 2020-07-08 /pmc/articles/PMC7450605/ /pubmed/32923590 http://dx.doi.org/10.1126/sciadv.aba5855 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Magdanz, Veronika Khalil, Islam S. M. Simmchen, Juliane Furtado, Guilherme P. Mohanty, Sumit Gebauer, Johannes Xu, Haifeng Klingner, Anke Aziz, Azaam Medina-Sánchez, Mariana Schmidt, Oliver G. Misra, Sarthak IRONSperm: Sperm-templated soft magnetic microrobots |
title | IRONSperm: Sperm-templated soft magnetic microrobots |
title_full | IRONSperm: Sperm-templated soft magnetic microrobots |
title_fullStr | IRONSperm: Sperm-templated soft magnetic microrobots |
title_full_unstemmed | IRONSperm: Sperm-templated soft magnetic microrobots |
title_short | IRONSperm: Sperm-templated soft magnetic microrobots |
title_sort | ironsperm: sperm-templated soft magnetic microrobots |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450605/ https://www.ncbi.nlm.nih.gov/pubmed/32923590 http://dx.doi.org/10.1126/sciadv.aba5855 |
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