Synthesis and Evaluation of Biphenyl-1,2,3-Triazol-Benzonitrile Derivatives as PD-1/PD-L1 Inhibitors

[Image: see text] In this study, we designed and synthesized a series of 3-(4-((5-((2-methylbiphenyl-3-yl) methoxy)-2-(piperazin-1-ylmethyl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)benzonitrile derivatives and examined the effect of the compounds on the interaction between PD-1 and PD-L1. Among the new...

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Detalles Bibliográficos
Autores principales: Narva, Suresh, Xiong, Xuqiong, Ma, Xudong, Tanaka, Yoshimasa, Wu, Yanling, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450630/
https://www.ncbi.nlm.nih.gov/pubmed/32875254
http://dx.doi.org/10.1021/acsomega.0c02916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450630/
https://www.ncbi.nlm.nih.gov/pubmed/32875254
http://dx.doi.org/10.1021/acsomega.0c02916

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