Cargando…

APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stress

BACKGROUND: Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular disease and associate with the disease progression, but the molecular mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wakashin, Hidefumi, Heymann, Jurgen, Roshanravan, Hila, Daneshpajouhnejad, Parnaz, Rosenberg, Avi, Shin, Myung Kyun, Hoek, Maarten, Kopp, Jeffrey B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450955/ https://www.ncbi.nlm.nih.gov/pubmed/32854642 http://dx.doi.org/10.1186/s12882-020-01995-3

Ejemplares similares

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice
por: Ryu, Jung-Hwa, et al.
Publicado: (2019)

Transcriptomic Analysis of Human Podocytes In Vitro: Effects of Differentiation and APOL1 Genotype
por: Yoshida, Teruhiko, et al.
Publicado: (2022)

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R
por: Okamoto, Koji, et al.
Publicado: (2018)

The evolving story of apolipoprotein L1 nephropathy: the end of the beginning
por: Daneshpajouhnejad, Parnaz, et al.
Publicado: (2022)

Lessons From APOL1 Animal Models
por: Yoshida, Teruhiko, et al.
Publicado: (2021)

Podocytes Degrade Endocytosed Albumin Primarily in Lysosomes
por: Carson, John M., et al.
Publicado: (2014)

APOL1 polymorphism modulates sphingolipid profile of human podocytes
por: Valsecchi, Manuela, et al.
Publicado: (2020)

APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress
por: Wen, Hongxiu, et al.
Publicado: (2018)

PodoCount: A Robust, Fully Automated, Whole-Slide Podocyte Quantification Tool
por: Santo, Briana A., et al.
Publicado: (2022)

Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys
por: Blessing, Natalya A., et al.
Publicado: (2021)

Effect of APOL1 disease risk variants on APOL1 gene product
por: Haque, Shabirul, et al.
Publicado: (2017)

20-Hydroxyeicosatetraenoic Acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes
por: Roshanravan, Hila, et al.
Publicado: (2016)

Transcription and translation of APOL1 variants
por: Ejaz, Samina
Publicado: (2017)

APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy
por: Bruggeman, Leslie A., et al.
Publicado: (2019)

Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells
por: Tzukerman, Maty, et al.
Publicado: (2022)

Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury
por: Andrews, Michael, et al.
Publicado: (2022)

Medical Students’ and Physicians’ Attitudes toward Patients’ Consent to Participate in Clinical Training
por: OMID, ATHAR, et al.
Publicado: (2015)

Impact of APOL1 Genetic Variants on HIV-1 Infection and Disease Progression
por: An, Ping, et al.
Publicado: (2019)

Disruption of APOL1-miR193a Axis Induces Disorganization of Podocyte Actin Cytoskeleton
por: Kumar, Vinod, et al.
Publicado: (2019)

Launching APOLLO: The Role of APOL1 Genetic Variants in Live- and Deceased-Donor Kidney Transplantation
por: Fuentes, Federico, et al.
Publicado: (2019)

APOL1 Risk Variants Independently Associated With Early Cardiovascular Disease Death
por: Hughson, Michael D., et al.
Publicado: (2017)

Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes
por: Mikulak, Joanna, et al.
Publicado: (2016)

APOL1 variants contribute to racial disparity in sepsis
por: Bird, Lucy
Publicado: (2021)

Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
por: Pell, John, et al.
Publicado: (2023)

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin
por: Uzureau, Sophie, et al.
Publicado: (2020)

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis
por: Cooper, Anneli, et al.
Publicado: (2017)

Novel Human Podocyte Cell Model Carrying G2/G2 APOL1 High-Risk Genotype
por: Ekulu, Pepe M., et al.
Publicado: (2021)

APOL1 variant alleles associate with reduced risk for opportunistic infections in HIV infection
por: An, Ping, et al.
Publicado: (2021)

Sequencing rare and common APOL1 coding variants to determine kidney disease risk
por: Limou, Sophie, et al.
Publicado: (2015)

APOL1 Toxin, Innate Immunity and Kidney Injury
por: Limou, Sophie, et al.
Publicado: (2015)

Copy Number Variation at the APOL1 Locus
por: Ruchi, Rupam, et al.
Publicado: (2015)

APOL1 Kidney-Risk Variants Induce Mitochondrial Fission
por: Ma, Lijun, et al.
Publicado: (2020)

RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes
por: Bundy, Joseph L., et al.
Publicado: (2019)

APOL1 Risk Alleles Are Associated With More Severe Arteriosclerosis in Renal Resistance Vessels With Aging and Hypertension
por: Hughson, Michael D., et al.
Publicado: (2016)

Fetal—Not Maternal—APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry
por: Reidy, Kimberly J., et al.
Publicado: (2018)

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense
por: Cooper, Anneli, et al.
Publicado: (2016)

HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria
por: Kruzel-Davila, Etty, et al.
Publicado: (2021)

The kidney of the Nodularia freshwater mussel has a larger filtration-size and counter-current system with improved water excretion compared with the seawater mussel Mytilus
por: Seo, Eriko, et al.
Publicado: (2021)

Gastroesophageal Reflux Disease in Iran: SEPAHAN Systematic Review No. 2
por: Fazel, Mohammadreza, et al.
Publicado: (2012)

Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway
por: Davis, Shamara E., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_47dt5n62tktnicq7joaomij593