Structure and flexibility in cortical representations of odor space

The cortex organizes sensory information to enable discrimination and generalization(1–4). Systematic representations of chemical odor space have not been described in olfactory cortex, and so it remains unclear how odor relationships are encoded to place chemically distinct but similar odors, like lemon and orange, into perceptual categories, like citrus(5–7). Here we demonstrate that both the piriform cortex (PCx) and its sensory inputs from the olfactory bulb represent chemical odor relationships through correlated patterns of activity. However, cortical odor codes differ from those in the bulb: cortex more strongly clusters together representations for related odors, selectively rewrites pairwise odor relationships, and better matches odor perception. The bulb-to-cortex transformation depends upon the associative network originating within PCx, and can be reshaped by passive odor experience. Thus, cortex actively builds a structured representation of chemical odor space that highlights odor relationships; this representation is similar across individuals but remains plastic, suggesting a means through which the olfactory system can assign related odor cues to common and yet personalized percepts.