Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer

Opioid abuse and HIV/AIDS have been defined as synergistic epidemics. Opioids can accelerate HIV replication in the immune system by up-regulating the expression of HIV co-receptor CXCR4. Several hypotheses have been suggested as the mechanism of CXCR4 modulation by opioids through their activation...

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Detalles Bibliográficos
Autores principales: Reinecke, Bethany A., Kang, Guifeng, Zheng, Yi, Obeng, Samuel, Zhang, Huijun, Selley, Dana E., An, Jing, Zhang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451026/
https://www.ncbi.nlm.nih.gov/pubmed/33479612
http://dx.doi.org/10.1039/c9md00433e

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