Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity

BACKGROUND: Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor immunity against immunogenic tumors in mice, prompting clinical trials to test STING activators. However, STING signaling in the tumor microenvironment (TME) during development of Lewis lung carcinoma (LLC) s...

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Detalles Bibliográficos
Autores principales: Lemos, Henrique, Ou, Rong, McCardle, Caroline, Lin, Yijun, Calver, Jessica, Minett, Jack, Chadli, Ahmed, Huang, Lei, Mellor, Andrew L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451475/
https://www.ncbi.nlm.nih.gov/pubmed/32847988
http://dx.doi.org/10.1136/jitc-2020-001182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451475/
https://www.ncbi.nlm.nih.gov/pubmed/32847988
http://dx.doi.org/10.1136/jitc-2020-001182

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