Cargando…

Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models

OBJECTIVE: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. METHODS: The healthy male Sprague wrote – Dawley (SD) rats were taken as the research object, and they were randomly divided into model gr...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Zhenlong, Wang, Lei, Li, Guoyan, Qian, Xuwen, Zhang, Jie, Guo, Ying, Liu, Guokai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451692/
https://www.ncbi.nlm.nih.gov/pubmed/32874123
http://dx.doi.org/10.1016/j.sjbs.2020.05.043
_version_ 1783575030058188800
author Qin, Zhenlong
Wang, Lei
Li, Guoyan
Qian, Xuwen
Zhang, Jie
Guo, Ying
Liu, Guokai
author_facet Qin, Zhenlong
Wang, Lei
Li, Guoyan
Qian, Xuwen
Zhang, Jie
Guo, Ying
Liu, Guokai
author_sort Qin, Zhenlong
collection PubMed
description OBJECTIVE: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. METHODS: The healthy male Sprague wrote – Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. RESULTS: The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. CONCLUSION: Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve.
format Online
Article
Text
id pubmed-7451692
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-74516922020-08-31 Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models Qin, Zhenlong Wang, Lei Li, Guoyan Qian, Xuwen Zhang, Jie Guo, Ying Liu, Guokai Saudi J Biol Sci Article OBJECTIVE: To investigate the analgesic effect of amitriptyline on neuropathic pain model rats, diabetic neuropathic pain model rats and fibromyalgia model rats. METHODS: The healthy male Sprague wrote – Dawley (SD) rats were taken as the research object, and they were randomly divided into model group (group A), beside the sciatic nerve and injection of 5 mm amitriptyline group (group B), beside the sciatic nerve and injection of 10 mm amitriptyline group (group C), beside the sciatic nerve and injection of 15 mm amitriptyline group (group D), intraperitoneal injection of amitriptyline group (group E). Pain induced by selective injury of sciatic nerve branches in rats, pain induced by chronic compression of sciatic nerve, diabetic neuropathic pain and fibromyalgia were conducted to determine the pain threshold of mechanical stimulation in rats after drug administration. RESULTS: The pain threshold of mechanical stimulation in the local amitriptyline group (group B, C, D) was significantly higher than that in the group A and group E at each time point after drug treatment, and the pain threshold of mechanical stimulation gradually increased with the increase of concentration. There was no statistically significant difference in mechanical stimulation pain threshold between group A and group E at each time point after drug treatment. CONCLUSION: Para-sciatic injection of amitriptyline at different concentrations has analgesic effects on neuropathic pain, diabetic neuropathic pain and fibromyalgia in rat models, and amitriptyline directly ACTS on the local sciatic nerve. Elsevier 2020-09 2020-06-01 /pmc/articles/PMC7451692/ /pubmed/32874123 http://dx.doi.org/10.1016/j.sjbs.2020.05.043 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Qin, Zhenlong
Wang, Lei
Li, Guoyan
Qian, Xuwen
Zhang, Jie
Guo, Ying
Liu, Guokai
Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
title Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
title_full Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
title_fullStr Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
title_full_unstemmed Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
title_short Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
title_sort analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451692/
https://www.ncbi.nlm.nih.gov/pubmed/32874123
http://dx.doi.org/10.1016/j.sjbs.2020.05.043
work_keys_str_mv AT qinzhenlong analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels
AT wanglei analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels
AT liguoyan analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels
AT qianxuwen analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels
AT zhangjie analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels
AT guoying analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels
AT liuguokai analysisoftheanalgesiceffectsoftricyclicantidepressantsonneuropathicpaindiabeticneuropathicpainandfibromyalgiainratmodels