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Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water
Marine species are increasingly important as a source of specific biological active metabolites. Marine species comprise almost half of global biodiversity. Oceans and sea are thus the biggest source of positive natural compounds that could be utilized in the pharmaceutical industry as functional co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451693/ https://www.ncbi.nlm.nih.gov/pubmed/32884422 http://dx.doi.org/10.1016/j.sjbs.2020.05.007 |
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author | Shanthi Kumari, K. Shivakrishna, Pabba Ganduri, V.S. Ramakrishna |
author_facet | Shanthi Kumari, K. Shivakrishna, Pabba Ganduri, V.S. Ramakrishna |
author_sort | Shanthi Kumari, K. |
collection | PubMed |
description | Marine species are increasingly important as a source of specific biological active metabolites. Marine species comprise almost half of global biodiversity. Oceans and sea are thus the biggest source of positive natural compounds that could be utilized in the pharmaceutical industry as functional constituents. In the present study was to find out the wound healing property of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine source. The in vivo wound healing activity was studied using excision wound model. The KLUF 10 and KLUF13 ointment was prepared and used to determine wound healing activity in albino rats. Topical application of the ointment enhanced the contraction of wound in contrast with rat control group. KLUF13 had shown strong healing ability in wounds and had a positive influence on the various phases of wound repair. |
format | Online Article Text |
id | pubmed-7451693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74516932020-09-02 Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water Shanthi Kumari, K. Shivakrishna, Pabba Ganduri, V.S. Ramakrishna Saudi J Biol Sci Article Marine species are increasingly important as a source of specific biological active metabolites. Marine species comprise almost half of global biodiversity. Oceans and sea are thus the biggest source of positive natural compounds that could be utilized in the pharmaceutical industry as functional constituents. In the present study was to find out the wound healing property of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine source. The in vivo wound healing activity was studied using excision wound model. The KLUF 10 and KLUF13 ointment was prepared and used to determine wound healing activity in albino rats. Topical application of the ointment enhanced the contraction of wound in contrast with rat control group. KLUF13 had shown strong healing ability in wounds and had a positive influence on the various phases of wound repair. Elsevier 2020-09 2020-05-11 /pmc/articles/PMC7451693/ /pubmed/32884422 http://dx.doi.org/10.1016/j.sjbs.2020.05.007 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Shanthi Kumari, K. Shivakrishna, Pabba Ganduri, V.S. Ramakrishna Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water |
title | Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water |
title_full | Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water |
title_fullStr | Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water |
title_full_unstemmed | Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water |
title_short | Wound healing Activities of the bioactive compounds from Micrococcus sp. OUS9 isolated from marine water |
title_sort | wound healing activities of the bioactive compounds from micrococcus sp. ous9 isolated from marine water |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451693/ https://www.ncbi.nlm.nih.gov/pubmed/32884422 http://dx.doi.org/10.1016/j.sjbs.2020.05.007 |
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