Inhibitory and inductive effects of 4- or 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, on several forms of cytochrome P450 in primary cultured rat and human hepatocytes

Effects of 4-methyl-2-mercaptobenzimidazole (4-MeMBI) and 5-methyl-2- mercaptobenzimidazole (5-MeMBI) on cytochrome P450 (CYP) activity were examined in primary cultured rat hepatocytes. Hepatocytes from male Wistar rats were cultured in the presence of 4-MeMBI or 5-MeMBI (0−400 μM), and the activit...

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Detalles Bibliográficos
Autores principales: Miyajima, Atsuko, Kuroda, Yukie, Sakemi-Hoshikawa, Kazue, Usami, Makoto, Mitsunaga, Katsuyoshi, Irie, Tomohiko, Ohno, Yasuo, Sunouchi, Momoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451710/
https://www.ncbi.nlm.nih.gov/pubmed/32874920
http://dx.doi.org/10.1016/j.toxrep.2020.08.003

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