Oncogenic fusion protein FGFR2-PPHLN1: Requirements for biological activation, and efficacy of inhibitors

AIM OF STUDY: Chromosomal translocations such as t(10;12)(q26,q12) are associated with intrahepatic cholangiocarcinoma, a universally fatal category of liver cancer. This translocation creates the oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 joined to Periphilin 1. The aims of thi...

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Detalles Bibliográficos
Autores principales: Li, Fangda, Meyer, April N., Peiris, Malalage N., Nelson, Katelyn N., Donoghue, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451725/
https://www.ncbi.nlm.nih.gov/pubmed/32854034
http://dx.doi.org/10.1016/j.tranon.2020.100853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451725/
https://www.ncbi.nlm.nih.gov/pubmed/32854034
http://dx.doi.org/10.1016/j.tranon.2020.100853

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