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Fractional design: An alternative paradigm for late-onset toxicities in oncology dose-finding studies
Late-onset (LO) toxicities often arise in the new era of phase I oncology dose-finding trials with targeted agents or immunotherapies. The current LO toxicities modelling is often formulated in a weighted likelihood framework, where the time-to-event continual reassessment method (TITE-CRM) is commo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451759/ https://www.ncbi.nlm.nih.gov/pubmed/32875142 http://dx.doi.org/10.1016/j.conctc.2020.100650 |