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Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases
Fibrotic diseases cause annually more than 800,000 deaths worldwide, where of the majority accounts for cardiovascular fibrosis, which is characterized by endothelial dysfunction, myocardial stiffening and reduced dispensability. MicroRNAs (miRs), small noncoding RNAs, play critical roles in cardiov...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer US
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451782/ https://www.ncbi.nlm.nih.gov/pubmed/32856216 http://dx.doi.org/10.1007/s12012-020-09603-4 |
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author | Liu, Ying Song, Jia-Wei Lin, Jian-Yu Miao, Ran Zhong, Jiu-Chang |
author_facet | Liu, Ying Song, Jia-Wei Lin, Jian-Yu Miao, Ran Zhong, Jiu-Chang |
author_sort | Liu, Ying |
collection | PubMed |
description | Fibrotic diseases cause annually more than 800,000 deaths worldwide, where of the majority accounts for cardiovascular fibrosis, which is characterized by endothelial dysfunction, myocardial stiffening and reduced dispensability. MicroRNAs (miRs), small noncoding RNAs, play critical roles in cardiovascular dysfunction and related disorders. Intriguingly, there is a critical link among miR-122, cardiovascular fibrosis, sirtuin 6 (SIRT6) and angiotensin-converting enzyme 2 (ACE2), which was recently identified as a coreceptor for SARS-CoV2 and a negative regulator of the rennin-angiotensin system. MiR-122 overexpression appears to exacerbate the angiotensin II-mediated loss of autophagy and increased inflammation, apoptosis, extracellular matrix deposition, cardiovascular fibrosis and dysfunction by modulating the SIRT6-Elabela-ACE2, LGR4-β-catenin, TGFβ-CTGF and PTEN-PI3K-Akt signaling pathways. More importantly, the inhibition of miR-122 has proautophagic, antioxidant, anti-inflammatory, anti-apoptotic and antifibrotic effects. Clinical and experimental studies clearly demonstrate that miR-122 functions as a crucial hallmark of fibrogenesis, cardiovascular injury and dysfunction. Additionally, the miR-122 level is related to the severity of hypertension, atherosclerosis, atrial fibrillation, acute myocardial infarction and heart failure, and miR-122 expression is a risk factor for these diseases. The miR-122 level has emerged as an early-warning biomarker cardiovascular fibrosis, and targeting miR-122 is a novel therapeutic approach against progression of cardiovascular dysfunction. Therefore, an increased understanding of the cardiovascular roles of miR-122 will help the development of effective interventions. This review summarizes the biogenesis of miR-122; regulatory effects and underlying mechanisms of miR-122 on cardiovascular fibrosis and related diseases; and its function as a potential specific biomarker for cardiovascular dysfunction. |
format | Online Article Text |
id | pubmed-7451782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-74517822020-08-28 Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases Liu, Ying Song, Jia-Wei Lin, Jian-Yu Miao, Ran Zhong, Jiu-Chang Cardiovasc Toxicol Article Fibrotic diseases cause annually more than 800,000 deaths worldwide, where of the majority accounts for cardiovascular fibrosis, which is characterized by endothelial dysfunction, myocardial stiffening and reduced dispensability. MicroRNAs (miRs), small noncoding RNAs, play critical roles in cardiovascular dysfunction and related disorders. Intriguingly, there is a critical link among miR-122, cardiovascular fibrosis, sirtuin 6 (SIRT6) and angiotensin-converting enzyme 2 (ACE2), which was recently identified as a coreceptor for SARS-CoV2 and a negative regulator of the rennin-angiotensin system. MiR-122 overexpression appears to exacerbate the angiotensin II-mediated loss of autophagy and increased inflammation, apoptosis, extracellular matrix deposition, cardiovascular fibrosis and dysfunction by modulating the SIRT6-Elabela-ACE2, LGR4-β-catenin, TGFβ-CTGF and PTEN-PI3K-Akt signaling pathways. More importantly, the inhibition of miR-122 has proautophagic, antioxidant, anti-inflammatory, anti-apoptotic and antifibrotic effects. Clinical and experimental studies clearly demonstrate that miR-122 functions as a crucial hallmark of fibrogenesis, cardiovascular injury and dysfunction. Additionally, the miR-122 level is related to the severity of hypertension, atherosclerosis, atrial fibrillation, acute myocardial infarction and heart failure, and miR-122 expression is a risk factor for these diseases. The miR-122 level has emerged as an early-warning biomarker cardiovascular fibrosis, and targeting miR-122 is a novel therapeutic approach against progression of cardiovascular dysfunction. Therefore, an increased understanding of the cardiovascular roles of miR-122 will help the development of effective interventions. This review summarizes the biogenesis of miR-122; regulatory effects and underlying mechanisms of miR-122 on cardiovascular fibrosis and related diseases; and its function as a potential specific biomarker for cardiovascular dysfunction. Springer US 2020-08-27 2020 /pmc/articles/PMC7451782/ /pubmed/32856216 http://dx.doi.org/10.1007/s12012-020-09603-4 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Liu, Ying Song, Jia-Wei Lin, Jian-Yu Miao, Ran Zhong, Jiu-Chang Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases |
title | Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases |
title_full | Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases |
title_fullStr | Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases |
title_full_unstemmed | Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases |
title_short | Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases |
title_sort | roles of microrna-122 in cardiovascular fibrosis and related diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451782/ https://www.ncbi.nlm.nih.gov/pubmed/32856216 http://dx.doi.org/10.1007/s12012-020-09603-4 |
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