Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma

INTRODUCTION: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated mortality globally. Immune-checkpoint blockade (ICB) is one of the systemic therapy options for HCC. However, response rates remain low, necessitating robust predictive biomarkers. In the present study, we...

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Detalles Bibliográficos
Autores principales: Ng, Harry Ho Man, Lee, Ren Yuan, Goh, Siting, Tay, Isabel Shu Ying, Lim, Xinru, Lee, Bernett, Chew, Valerie, Li, Huihua, Tan, Benedict, Lim, Sherlly, Lim, Jeffrey Chun Tatt, Au, Bijin, Loh, Josh Jie Hua, Saraf, Sahil, Connolly, John Edward, Loh, Tracy, Leow, Wei Qiang, Lee, Joycelyn Jie Xin, Toh, Han Chong, Malavasi, Fabio, Lee, Ser Yee, Chow, Pierce, Newell, Evan W, Choo, Su Pin, Tai, David, Yeong, Joe, Lim, Tony Kiat Hon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451957/
https://www.ncbi.nlm.nih.gov/pubmed/32847986
http://dx.doi.org/10.1136/jitc-2020-000987

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