Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

Hepsin, a transmembrane serine protease abundant in renal endothelial cells, is a promising therapeutic target against several cancers, particularly prostate cancer. It is involved in the release and polymerization of uromodulin in the urine, which plays a role in kidney stone formation. In this wor...

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Detalles Bibliográficos
Autores principales: Blay, Vincent, Li, Mu-Chun, Ho, Sunita P., Stoller, Mashall L., Hsieh, Hsing-Pang, Houston, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452031/
https://www.ncbi.nlm.nih.gov/pubmed/32874830
http://dx.doi.org/10.1016/j.apsb.2019.09.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452031/
https://www.ncbi.nlm.nih.gov/pubmed/32874830
http://dx.doi.org/10.1016/j.apsb.2019.09.008

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