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Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
Hepsin, a transmembrane serine protease abundant in renal endothelial cells, is a promising therapeutic target against several cancers, particularly prostate cancer. It is involved in the release and polymerization of uromodulin in the urine, which plays a role in kidney stone formation. In this wor...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452031/ https://www.ncbi.nlm.nih.gov/pubmed/32874830 http://dx.doi.org/10.1016/j.apsb.2019.09.008 |