Evaluation of (124)I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice

JS001 (toripalimab) is a humanized IgG monoclonal antibody which strongly inhibits programmed cell death protein 1 (PD1). In this study, we used a different iodine isotype ((nat/124/125)I) to label JS001 probes to target the human PD1 (hPD1) antigen. In vitro, the half maximal effective concentratio...

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Detalles Bibliográficos
Autores principales: Huang, Haifeng, Zhu, Hua, Xie, Quan, Tian, Xiaobin, Yang, Xianteng, Feng, Fan, Jiang, Qiyu, Sheng, Xinan, Yang, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452040/
https://www.ncbi.nlm.nih.gov/pubmed/32874831
http://dx.doi.org/10.1016/j.apsb.2020.02.004

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