Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia

Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs’ targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-I editing of the primary (pri-)microRNAs in vascular...

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Detalles Bibliográficos
Autores principales: van der Kwast, Reginald V.C.T., Parma, Laura, van der Bent, M. Leontien, van Ingen, Eva, Baganha, Fabiana, Peters, Hendrika A.B., Goossens, Eveline A.C., Simons, Karin H., Palmen, Meindert, de Vries, Margreet R., Quax, Paul H.A., Nossent, A. Yaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452086/
https://www.ncbi.nlm.nih.gov/pubmed/32814251
http://dx.doi.org/10.1016/j.omtn.2020.07.020

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